TM7SF3 Inhibitors
TM7SF3 inhibitors belong to a specialized class of chemical compounds designed to target and modulate the activity of TM7SF3, also known as Transmembrane 7 Superfamily Member 3. TM7SF3 is a protein found in cell membranes and is associated with lipid metabolism, particularly in the context of cholesterol biosynthesis. While the precise functions of TM7SF3 are still under investigation, it is believed to play a pivotal role in regulating cholesterol production within cells. Inhibitors of TM7SF3 are developed to interact with this specific protein, potentially influencing its activity, interactions with other cellular components, or its role in lipid metabolism, particularly cholesterol biosynthesis.
Structurally, TM7SF3 inhibitors are meticulously designed to engage specific regions or binding sites on the TM7SF3 protein. This interaction can disrupt the normal functioning of TM7SF3, potentially altering its role in cholesterol biosynthesis or other lipid-related pathways. The mechanisms by which TM7SF3 inhibitors exert their effects can vary, but their primary aim is to serve as invaluable tools for researchers studying the roles of TM7SF3 in various cellular contexts. Investigating the biochemical and functional aspects of TM7SF3 and its modulation by inhibitors can contribute to a deeper understanding of lipid metabolism, cholesterol biosynthesis, and the broader field of molecular and cellular biology. Ultimately, such research can offer insights into the intricate molecular mechanisms that govern fundamental cellular functions and their potential regulation by TM7SF3, paving the way for a better understanding of cholesterol metabolism and related cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
An inhibitor of γ-secretase, affecting many transmembrane proteins' processing and potentially affecting TM7SF3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that affects transmembrane receptor signaling pathways. Might indirectly influence TM7SF3. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts protein trafficking between the ER & Golgi, potentially influencing transmembrane proteins like TM7SF3. | ||||||
WZ4003 | 1214265-58-3 | sc-473979 | 5 mg | $300.00 | ||
NUAK kinase inhibitor, which might indirectly affect transmembrane protein signaling. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Inhibits dynamin, affecting endocytosis of many transmembrane proteins. Might have an impact on TM7SF3 pathways. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $203.00 $611.00 | 24 | |
Neutral sphingomyelinase inhibitor affecting lipid rafts and transmembrane signaling. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
A calcium ionophore that can disrupt transmembrane ion balances and potentially impact TM7SF3. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A broad tyrosine kinase inhibitor that can potentially modulate transmembrane protein signaling. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Myosin light chain kinase inhibitor which might have indirect effects on transmembrane signaling. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
An ionophore that disrupts transmembrane ion balances. Might have some influence on TM7SF3 activity. | ||||||