Date published: 2025-10-25

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Tim9A Inhibitors

Tim9A, a protein component of the Tim9-Tim10-Tim12 complex, plays a crucial role in the mitochondrial intermembrane space (IMS) and is involved in the import and assembly of proteins into the inner mitochondrial membrane (IMM). The Tim9-Tim10-Tim12 complex functions as a chaperone for the transport of hydrophobic proteins across the IMS, facilitating their insertion into the IMM and contributing to the biogenesis of respiratory chain complexes. Tim9A specifically interacts with Tim10 and Tim12 to form a stable complex, which aids in the translocation of precursor proteins from the cytosol into the mitochondrial matrix. This process is essential for the proper functioning of mitochondria, as it ensures the correct assembly and activity of respiratory chain complexes, which are crucial for cellular energy production and metabolism. The inhibition of Tim9A poses a significant challenge due to its essential role in mitochondrial protein import and assembly. However, strategies for inhibiting Tim9A involve disrupting its interactions with other components of the Tim9-Tim10-Tim12 complex or interfering with its function in protein translocation. For instance, small molecules or peptides that target specific domains of Tim9A involved in complex formation or protein binding prevents the assembly of the Tim9-Tim10-Tim12 complex, thereby inhibiting its chaperone activity. Additionally, compounds that interfere with the proper folding or stability of Tim9A could disrupt its function in protein translocation, leading to impaired mitochondrial biogenesis and function. Understanding the precise molecular mechanisms underlying the function of Tim9A and its interactions within the mitochondrial import machinery is crucial for the development of effective inhibitors targeting this protein and modulating mitochondrial function in various physiological and pathological conditions.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Carbonyl Cyanide m-Chlorophenylhydrazone

555-60-2sc-202984A
sc-202984
sc-202984B
100 mg
250 mg
500 mg
$75.00
$150.00
$235.00
8
(1)

CCCP is an uncoupler of oxidative phosphorylation in mitochondria. By disrupting the mitochondrial membrane potential, it can indirectly inhibit the function of Tim9A, which relies on this potential for protein import.

Oligomycin

1404-19-9sc-203342
sc-203342C
10 mg
1 g
$146.00
$12250.00
18
(2)

Oligomycin is an inhibitor of ATP synthase. By reducing the production of ATP, it can interfere with ATP-dependent processes in the mitochondria, potentially influencing the function of Tim9A.

Valinomycin

2001-95-8sc-200991
25 mg
$163.00
3
(1)

Valinomycin is a potassium ionophore that disrupts the mitochondrial membrane potential. The disruption can indirectly inhibit the function of Tim9A, as a stable membrane potential is needed for protein import.

Antimycin A

1397-94-0sc-202467
sc-202467A
sc-202467B
sc-202467C
5 mg
10 mg
1 g
3 g
$54.00
$62.00
$1642.00
$4600.00
51
(1)

Antimycin A inhibits the electron transport chain, disrupting ATP production. This could potentially affect the function of Tim9A, which may rely on ATP for protein import.

Rotenone

83-79-4sc-203242
sc-203242A
1 g
5 g
$89.00
$254.00
41
(1)

Rotenone inhibits complex I of the mitochondrial electron transport chain. By reducing ATP production, it can interfere with ATP-dependent processes in the mitochondria, potentially influencing the function of Tim9A.

DCC

538-75-0sc-239713
sc-239713A
25 g
100 g
$71.00
$204.00
3
(1)

DCC is an inhibitor of ATP synthase. By reducing ATP production, it can inhibit ATP-dependent processes in the mitochondria, potentially influencing the function of Tim9A.

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$169.00
$299.00
66
(3)

Tunicamycin inhibits N-linked glycosylation, a post-translational modification. While not specific to mitochondria, it could potentially affect proteins that interact with Tim9A.

α-Iodoacetamide

144-48-9sc-203320
25 g
$250.00
1
(1)

Iodoacetamide inhibits cysteine proteases, which are involved in protein degradation. It might indirectly influence Tim9A by affecting protein quality control in the mitochondria.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$30.00
$52.00
$122.00
$367.00
25
(3)

Brefeldin A disrupts protein transport from the endoplasmic reticulum to the Golgi apparatus. It might indirectly affect Tim9A by altering cellular protein trafficking.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

Cycloheximide inhibits protein synthesis. While not directly inhibiting Tim9A, it can broadly affect protein import by reducing the availability of new proteins.