Tim14 Activators
Tim14, scientifically known as a subunit of the presequence translocase-associated motor (PAM) complex, is a mitochondrially encoded protein that plays a pivotal role in the import and folding of precursor proteins into the mitochondrial matrix. Integral to the PAM complex, Tim14 is also referred to as PAM18 and is characterized by its interaction with the J-protein Tim16, which in turn modulates the ATPase activity of mitochondrial Hsp70. This interaction is crucial for the translocation of proteins across the mitochondrial inner membrane, a process essential for mitochondrial biogenesis and functionality. The proper function and regulation of Tim14 are therefore vital for maintaining mitochondrial integrity and, by extension, cellular energy homeostasis.
Within the cellular milieu, the expression of mitochondrial proteins such as Tim14 can be influenced by a variety of chemical compounds known as activators, which can upregulate the genetic pathways responsible for mitochondrial biogenesis and function. For instance, compounds like resveratrol have been linked to the upregulation of sirtuins, a family of proteins that promote mitochondrial biogenesis, potentially leading to increased expression of Tim14. Similarly, metformin, through its action on the AMP-activated protein kinase pathway, could stimulate a cascade of events culminating in enhanced mitochondrial proliferation and possibly augmented Tim14 levels. Other activators, such as rapamycin, bezafibrate, and PGC-1α activators like berberine, are known to influence mitochondrial dynamics through various signaling pathways. Whether by inhibiting mTOR signaling, engaging PPAR receptors, or directly activating the PGC-1α pathway, these activators may contribute to an upswing in the production of proteins essential for mitochondrial function. Importantly, the cellular response to these activators is a complex interplay of signaling networks that ultimately contribute to maintaining the equilibrium of mitochondrial protein import and assembly, with Tim14 being a critical component of this process.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to upregulate sirtuins, which in turn upregulate PGC-1α, a master regulator of mitochondrial biogenesis. This upregulation could stimulate the production of mitochondrial proteins, including Tim14, as the cell attempts to increase its mitochondrial capacity. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates AMP-activated protein kinase (AMPK), which can lead to an upsurge in mitochondrial biogenesis. This surge may necessitate an increase in mitochondrial proteins such as Tim14 to cope with the heightened biogenetic activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin's inhibition of the mTOR pathway could trigger a cellular energy stress response, leading to an upswing in the production of mitochondrial proteins, potentially including Tim14, to maintain energy balance. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate, as a PPAR agonist, can induce the expression of genes related to fatty acid oxidation, which are crucial for mitochondrial function. This could lead to a secondary upsurge in the expression of mitochondrial chaperones like Tim14. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine has been shown to activate PGC-1α, which can stimulate mitochondrial biogenesis and potentially lead to an upsurge in the expression of proteins necessary for mitochondrial function, including Tim14. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid has been implicated in the differentiation of cells and the subsequent increase in mitochondrial content, which could necessitate the upregulation of mitochondrial proteins such as Tim14. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside serves as a precursor to NAD+, which is essential for the function of sirtuins and may stimulate mitochondrial biogenesis, potentially leading to an increase in Tim14 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane is a strong inducer of the NRF2 pathway, which can lead to an increased expression of antioxidant defense genes and may extend to the induction of mitochondrial chaperone proteins like Tim14. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been linked to the upregulation of genes associated with mitochondrial function and could lead to enhanced assembly of mitochondrial proteins, possibly including Tim14, to support mitochondrial health. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine promotes autophagy, which could stimulate the turnover and renewal of mitochondria, potentially leading to increased expression of proteins like Tim14 as part of the mitochondrial quality control process. | ||||||