TIF1β Inhibitors
TIF1β inhibitors belong to a class of chemical compounds designed to selectively target and modulate the activity of Transcriptional Intermediary Factor 1 beta (TIF1β), also known as TRIM28 (Tripartite Motif Containing 28). TIF1β is a multifunctional protein that plays a crucial role in the regulation of gene expression and chromatin organization. It is a member of the TRIM family of proteins, which are involved in various cellular processes, including transcriptional regulation, DNA repair, and protein degradation. TIF1β is known to act as a corepressor by recruiting various epigenetic modifiers, such as histone deacetylases and DNA methyltransferases, to target genes, thereby influencing their transcriptional activity. TIF1β is also implicated in the formation of heterochromatin, a tightly packed and transcriptionally inactive form of chromatin.
TIF1β inhibitors are designed to disrupt the interaction between TIF1β and its binding partners, thus modulating its regulatory functions within the cell. By inhibiting TIF1β, these compounds alter gene expression patterns and chromatin structure, leading to downstream effects on various cellular processes. Researchers have been exploring the use of TIF1β inhibitors as valuable tools to investigate the molecular mechanisms of gene regulation and chromatin dynamics. These inhibitors have the ability to shed light on the roles of TIF1β in development, differentiation, and disease. Furthermore, understanding the precise functions of TIF1β and its interactions with other proteins may provide insights into novel strategies in the future, although such applications are beyond the scope of this description.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
As a histone deacetylase inhibitor, it might increase histone acetylation and alter the expression of genes including those regulating TIF1β. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 inhibits DNA methyltransferases, potentially changing the methylation status of genes involved in TIF1β expression regulation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
As a cytidine analog, it can be incorporated into DNA and inhibit methylation, possibly altering TIF1β expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
It can modulate proteasome activity, potentially affecting TIF1β levels. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
It binds to DNA and can interfere with transcription factor binding, potentially decreasing TIF1β transcription. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
As an isoflavone, it may act as a tyrosine kinase inhibitor and alter various signaling pathways, potentially reducing TIF1β expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
This compound from turmeric may modulate transcription factors and inflammatory pathways, possibly influencing TIF1β expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
By modulating sirtuin activity and other signaling pathways, it might impact the regulation of gene expression, including TIF1β. | ||||||