Date published: 2026-3-9

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Tie Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of Tie Antibodies for targeting the Tie family of receptor tyrosine kinases. Tie Antibodies are validated for multiple research applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Tie proteins are essential mediators in angiogenesis and lymphangiogenesis, directly influencing vascular development and homeostasis. The role of Tie proteins in endothelial cell signaling makes them particularly relevant in studies related to cancer, cardiovascular diseases, and tissue regeneration. Research focused on Tie proteins continues to reveal potential therapeutic targets for various pathologies. Investigating Tie protein functions has led to significant breakthroughs in understanding vascular system development and maintenance. Ongoing studies of Tie proteins contribute to advancing treatments for conditions affecting blood vessel formation and growth. Santa Cruz Biotechnology monoclonal antibodies for Tie proteins support researchers worldwide in making meaningful discoveries that advance vascular biology research.

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Tie Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

Tie-1 Antibody (G-12)

sc-365961mouse IgG2a κ25-204 (h)WB, IP, IF, ELISAh

new

(3)

Tie-1 Antibody (12D9)

sc-101587mouse IgG1(h)WB, IP, IF, IHC(P)h

new

(1)

Tie-1 Antibody (G-4)

sc-365257mouse IgG1 κ25-204 (h)WB, IP, IF, ELISAh

new

(1)

Tie-2 Antibody (F-6)

sc-518076mouse IgM κ65-88 (h)WB, IP, IF, ELISAh

new

(1)

Tie-2 Antibody (3A5)

sc-293414mouse IgG2a κ66-185 (h)WB, IP, ELISAm, r, h
11
(4)

Tie-2 Antibody (F-8)

sc-518137mouse IgM κ816-836 (h)WB, IP, IF, ELISAh

new

(1)

Tie CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Tie-2 CRISPR/Cas9 KO Plasmid (h)

sc-400295hGene KnockoutGFP0
(0)

Tie-2 HDR Plasmid (h)

sc-400295-HDRhHomology Directed RepairPuromycin0
(0)

Tie-2 CRISPR/Cas9 KO Plasmid (m)

sc-423334mGene KnockoutGFP0
(0)

Tie-2 HDR Plasmid (m)

sc-423334-HDRmHomology Directed RepairPuromycin0
(0)

Tie CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Tie-1 CRISPR Activation Plasmid (h)

sc-401506-ACThGene ActivationPuro, Blast, Hygro0
(0)

Tie-2 CRISPR Activation Plasmid (h)

sc-400295-ACThGene ActivationPuro, Blast, Hygro0
(0)

Tie-2 CRISPR Activation Plasmid (h2)

sc-400295-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

Tie siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Tie-1 siRNA (h)

sc-36675hGene SilencingN/A0
(0)

Tie-1 shRNA Plasmid (h)

sc-36675-SHhGene SilencingPuromycin0
(0)

Tie-1 shRNA (h) Lentiviral Particles

sc-36675-VhGene SilencingPuromycin0
(0)

Tie-1 siRNA (m)

sc-36676mGene SilencingN/A0
(0)

Tie-1 shRNA Plasmid (m)

sc-36676-SHmGene SilencingPuromycin0
(0)

Tie-1 shRNA (m) Lentiviral Particles

sc-36676-VmGene SilencingPuromycin0
(0)

Tie-2 siRNA (h)

sc-36677hGene SilencingN/A
10
(0)

Tie-2 shRNA Plasmid (h)

sc-36677-SHhGene SilencingPuromycin
10
(0)

Tie-2 shRNA (h) Lentiviral Particles

sc-36677-VhGene SilencingPuromycin
10
(0)

Tie-2 siRNA (m)

sc-36678mGene SilencingN/A
4
(0)

Tie-2 shRNA Plasmid (m)

sc-36678-SHmGene SilencingPuromycin
4
(0)

Tie-2 shRNA (m) Lentiviral Particles

sc-36678-VmGene SilencingPuromycin
4
(0)