Tie-1 Antibody (G-4): sc-365257
- Tie-1 Antibody (G-4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 25-204 of Tie-1 of human origin
- recommended for detection of Tie-1 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Tie-1 Antibody (G-4) for WB applications. This reagent is now offered in a bundle with Tie-1 Antibody (G-4) (see ordering information below).
Tie-1 Antibody (G-4) is a mouse monoclonal IgG1 antibody that detects Tie-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Tie-1 is a crucial receptor tyrosine kinase that plays a significant role in the regulation of endothelial cell function and vascular development. Tie-1′s unique multidomain structure, which includes three epidermal growth factor homology motifs and fibronectin type III repeats, is essential for interaction with other proteins and for mediating cellular signaling pathways. Proper functioning of Tie-1 is vital for maintaining vascular integrity and promoting angiogenesis, making Tie-1 a key player in both normal physiological processes and pathological conditions such as tumor growth and metastasis. Additionally, Tie-1 interacts with Tie-2 to form a complex signaling network that regulates blood vessel formation and stability. anti-Tie-1 antibody (G-4) is an invaluable tool for researchers studying these critical processes in human health and disease.
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Tie-1 Antibody (G-4) References:
- Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2. | Marron, MB., et al. 2000. J Biol Chem. 275: 39741-6. PMID: 10995770
- A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo. | Li, K., et al. 2010. Blood. 115: 133-9. PMID: 19880500
- An insoluble iron complex coated cathode enhances direct electron uptake by Rhodopseudomonas palustris TIE-1. | Rengasamy, K., et al. 2018. Bioelectrochemistry. 122: 164-173. PMID: 29655035
- Lessons learned from a lncRNA odyssey for two genes with vascular functions, DLL4 and TIE1. | Chowdhury, TA., et al. 2019. Vascul Pharmacol. 114: 103-109. PMID: 30910126
- Preclinical validation of a novel metastasis-inhibiting Tie1 function-blocking antibody. | Singhal, M., et al. 2020. EMBO Mol Med. 12: e11164. PMID: 32302470
- Potential of Tyrosine Kinase Receptor TIE-1 as Novel Therapeutic Target in High-PI3K-Expressing Ovarian Cancer. | Zhang, X., et al. 2020. Cancers (Basel). 12: PMID: 32604863
- FLI1 regulates radiotherapy resistance in nasopharyngeal carcinoma through TIE1-mediated PI3K/AKT signaling pathway. | Chen, E., et al. 2023. J Transl Med. 21: 134. PMID: 36814284
- Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2. | Cao, X., et al. 2023. Arterioscler Thromb Vasc Biol. 43: e323-e338. PMID: 37317851
- Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells. | Sato-Nishiuchi, R., et al. 2023. J Cell Biol. 222: PMID: 37338522
- Cerebrospinal Fluid C1-Esterase Inhibitor and Tie-1 Levels Affect Cognitive Performance: Evidence from Proteome-Wide Mendelian Randomization. | Zagkos, L., et al. 2024. Genes (Basel). 15: PMID: 38254961
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tie-1 Antibody (G-4) | sc-365257 | 200 µg/ml | $322.00 | |||
Tie-1 Antibody (G-4): m-IgG Fc BP-HRP Bundle | sc-540322 | 200 µg Ab; 10 µg BP | $361.00 |