TH Inhibitors
SEE ALSO...
Items 1 to 10 of 15 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benserazide·HCl (Ro 4-4602) | 14919-77-8 | sc-200723 sc-200723A | 100 mg 1 g | $26.00 $85.00 | ||
Benserazide·HCl is characterized by its ability to modulate neurotransmitter synthesis through selective inhibition of aromatic L-amino acid decarboxylase. Its unique structural features allow for specific binding interactions with the enzyme's active site, influencing reaction kinetics and substrate availability. The compound's hydrophilic nature enhances its solubility, promoting effective diffusion in biological systems, which is crucial for maintaining optimal enzymatic activity and metabolic balance. | ||||||
N-Methyl-L-tyrosine | 537-49-5 | sc-208044 | 250 mg | $236.00 | ||
N-Methyl-L-tyrosine acts as a competitive inhibitor of tyrosine hydroxylase, impacting catecholamine biosynthesis. Its structural conformation allows for effective interaction with the enzyme's active site, altering substrate affinity and reaction rates. The compound's unique steric properties facilitate specific molecular interactions, influencing metabolic pathways. Additionally, its moderate hydrophobicity affects membrane permeability, potentially altering cellular uptake and distribution dynamics. | ||||||
α-Methyl-D,L-tyrosine | 620-30-4 | sc-207231 | 2.5 g | $190.00 | ||
α-Methyl-D,L-tyrosine serves as a potent modulator of neurotransmitter synthesis by influencing the activity of aromatic amino acid decarboxylase. Its unique stereochemistry enhances binding affinity, leading to altered kinetics in enzymatic reactions. The compound's hydrophilic character promotes solubility in biological systems, while its ability to form hydrogen bonds can affect protein interactions. This interplay of properties contributes to its role in metabolic regulation and cellular signaling pathways. | ||||||
3-Iodo-L-tyrosine | 70-78-0 | sc-216471 sc-216471A sc-216471B | 1 g 5 g 25 g | $80.00 $200.00 $592.00 | ||
This compound inhibits TH by competing with its natural substrate, tyrosine. By doing so, it can decrease the synthesis of catecholamines. | ||||||
α-Methyl-L-p-tyrosine | 672-87-7 | sc-207232 | 25 mg | $260.00 | 1 | |
AMPT is a well-known inhibitor of TH. It competes with the substrate tyrosine, thereby reducing the production of DOPA and downstream catecholamines. | ||||||
α-Methyl-D,L-p-tyrosine, Methyl Ester, Hydrochloride | 7361-31-1 | sc-219470 | 1 g | $359.00 | 3 | |
α-Methyl-D,L-p-tyrosine, Methyl Ester, Hydrochloride exhibits distinctive characteristics as a TH, particularly in its interaction with enzymatic pathways. The compound's methyl ester group enhances lipophilicity, facilitating membrane permeability and influencing cellular uptake. Its structural conformation allows for specific interactions with active sites of enzymes, potentially altering reaction rates. Additionally, the presence of the hydrochloride salt form increases solubility, impacting its reactivity in various biochemical environments. | ||||||
Methacycline Hydrochloride | 3963-95-9 | sc-211806 sc-211806A | 100 mg 1 g | $96.00 $693.00 | ||
Metyrosine is a tyrosine analog and acts as a competitive inhibitor of TH, reducing catecholamine synthesis. | ||||||
6-Hydroxydopamine hydrochloride | 28094-15-7 | sc-203482 | 100 mg | $146.00 | 8 | |
While primarily a neurotoxin, 6-OHDA can inhibit TH, leading to reduced catecholamine synthesis. | ||||||
Fenamic acid | 91-40-7 | sc-202590 | 1 g | $20.00 | 1 | |
This compound has been shown to inhibit TH activity, potentially by competing with the cofactor tetrahydrobiopterin. | ||||||
7,8-Dihydroxyflavone | 38183-03-8 | sc-278634 | 100 mg | $51.00 | 2 | |
Although it has multiple cellular targets, 7,8-Dihydroxyflavone can inhibit TH and consequently reduce catecholamine synthesis. | ||||||