Molecular structure of N-Methyl-L-tyrosine, CAS Number: 537-49-5
N-Methyl-L-tyrosine (CAS 537-49-5)
Alternate Names:
N-Me-Tyr-OH⋅HCl
Application:
N-Methyl-L-tyrosine is a tyrosine hydroxylase inhibitor
CAS Number:
537-49-5
Molecular Weight:
195.22
Molecular Formula:
C10H13NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
N-Methyl-L-tyrosine is a TH (tyrosine hydroxylase) inhibitor, which suppresses the formation of DOPA from L-tyrosine. Tyrosine hydroxylase functions as an oxygenase, which is found in the cytosol of cells containing catecholamines. Inhibition of the enzyme leads to the depletion of dopamine and norepinephrine, as a result of the decrease in L-DOPA concentration. Furthermore, N-Methyl-L-tyrosine can be useful in research, which requires a regulation of tyrosine hydroxylase.
N-Methyl-L-tyrosine (CAS 537-49-5) References
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- Suberedamines A and B, new bromotyrosine alkaloids from a sponge Suberea species. | Tsuda, M., et al. 2001. J Nat Prod. 64: 980-2. PMID: 11473442
- Total synthesis and conformational analysis of the antifungal agent (-)-PF1163B. | Bouazza, F., et al. 2003. Org Lett. 5: 4049-52. PMID: 14572246
- Design of a small-molecule catalyst using intramolecular cation-pi interactions for enantioselective Diels-Alder and Mukaiyama-Michael reactions: L-DOPA-derived monopeptide.Cu(II) complex. | Ishihara, K. and Fushimi, M. 2006. Org Lett. 8: 1921-4. PMID: 16623585
- Mild and nonracemizing conditions for Ullmann-type diaryl ether formation between aryl iodides and tyrosine derivatives. | Cai, Q., et al. 2006. J Org Chem. 71: 5268-73. PMID: 16808515
- Total Synthesis and Pharmacological Investigation of Cordyheptapeptide A. | Kumar, S., et al. 2017. Molecules. 22: PMID: 28554994
- Effect of N-methyltyramine on the regulation of adrenergic receptors via enzymatic epinephrine synthesis for the treatment of gastrointestinal disorders. | Ni, J., et al. 2019. Biomed Pharmacother. 111: 1393-1398. PMID: 30841454
- Evidence for Naturally Produced Beauvericins Containing N-Methyl-Tyrosine in Hypocreales Fungi. | Urbaniak, M., et al. 2019. Toxins (Basel). 11: PMID: 30917588
- Methylated derivatives of l-tyrosine in reaction catalyzed by l-amino acid oxidase: isotope and inhibitory effects. | Pająk, M. 2020. J Biochem. 168: 509-514. PMID: 32569353
- Increased rate of catecholamine synthesis during respiratory acidosis. | Nahas, GG. and Steinsland, OS. 1968. Respir Physiol. 5: 108-17. PMID: 5682730
- Tyrosine hydroxylase. | Kaufman, S. 1995. Adv Enzymol Relat Areas Mol Biol. 70: 103-220. PMID: 8638482
- Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology. | Nagatsu, T. 1995. Essays Biochem. 30: 15-35. PMID: 8822146
- A Systematic Study of Ligand Effects on a Lewis-Acid-Catalyzed Diels−Alder Reaction in Water. Water-Enhanced Enantioselectivity | Sijbren Otto and Jan B. F. N. Engberts. 1999. J. Am. Chem. Soc. 1999,. 121, 29,: 6798–6806.
Inhibitor of:
TH.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Methyl-L-tyrosine, 250 mg | sc-208044 | 250 mg | $236.00 |