Molecular structure of 6-Hydroxydopamine hydrochloride, CAS Number: 28094-15-7
6-Hydroxydopamine hydrochloride (CAS 28094-15-7)
See product citations (8)
Alternate Names:
2,4,5-Trihydroxyphenethylamine hydrochloride; 2,5-Dihydroxytyramine hydrochloride; 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride; 6-OHDA
Application:
6-Hydroxydopamine hydrochloride is a selective catecholaminergic neurotoxin
CAS Number:
28094-15-7
Molecular Weight:
205.64
Molecular Formula:
C8H11NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
6-Hydroxydopamine hydrochloride is a selective catecholaminergic neurotoxin. It depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. It causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson′s disease.
6-Hydroxydopamine hydrochloride (CAS 28094-15-7) References
- Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. | Soto-Otero, R., et al. 2000. J Neurochem. 74: 1605-12. PMID: 10737618
- Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors. | Lane, EL., et al. 2005. J Pharmacol Exp Ther. 312: 1124-31. PMID: 15542624
- Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. | Fujita, H., et al. 2006. Brain Res. 1113: 10-23. PMID: 16945353
- Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson's disease in rats. | Pan, X., et al. 2015. Neurosci Lett. 600: 220-5. PMID: 26101828
- Effects of 6-hydroxydopamine-induced lesions of the paraventricular nucleus, and of prazosin, on the corticosterone response to restraint in rats. | Gibson, A., et al. 1986. Neuropharmacology. 25: 257-60. PMID: 2871514
- Simultaneous measurement of dopamine release and rotational behaviour in 6-hydroxydopamine denervated rats using intracerebral dialysis. | Zetterström, T., et al. 1986. Brain Res. 376: 1-7. PMID: 3087581
- Effect of Roucongrong (Herba Cistanches Deserticolae) decoction on the substantia nigra through Wnt/β-catenin signaling pathway in rats with Parkinson's disease induced by 6-hydroxydopamine hydrochloride. | Xu, Q., et al. 2021. J Tradit Chin Med. 41: 762-770. PMID: 34708635
- Blockage of amphetamine induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxydopamine. | Creese, I. and Iversen, SD. 1973. Brain Res. 55: 369-82. PMID: 4145950
- Effects of 6-hydroxydopamine on spontaneously hypertensive rats. | Vapaatalo, H., et al. 1974. Naunyn Schmiedebergs Arch Pharmacol. 284: 1-13. PMID: 4279346
- Effects of intracerebral injections of 6-hydroxydopamine on LH and FSH release in male rats. | Kitchen, JH. 1974. Neuroendocrinology. 15: 240-4. PMID: 4418702
- Effects of intraventricular injections of 6-hydroxydopamine on plasma LH and FSH in male rats. | Kitchen, JH., et al. 1974. J Reprod Fertil. 40: 249-57. PMID: 4430989
- Effect of central early postnatal 6-hydroxydopamine administration on brain catecholamines and pituitary-adrenal function in adulthood. | Kaplanski, J., et al. Neuroendocrinology. 13: 123-7. PMID: 4779045
- An ultrastructural and histochemical study of the short-term effects of 6-hydroxydopamine on adrenergic nerves in the domestic fowl. | Bennett, T., et al. 1970. Br J Pharmacol. 38: 802-9. PMID: 5441792
- Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons. | Breese, GR. and Traylor, TD. 1970. J Pharmacol Exp Ther. 174: 413-20. PMID: 5456173
- Ultrastructural localization of adrenergic nerve terminals in the circular muscle layer and muscularis mucosae of the rat duodenum after acute treatment with 6-hydroxydopamine. | Wong, WC. 1977. J Anat. 124: 637-42. PMID: 604333
- Bradycardia following injection of 6-hydroxydopamine into the intermediate portion of nucleus tractus solitarius medialis. | Healy, DP., et al. 1981. Brain Res. 206: 415-20. PMID: 7214141
- Effect of depletion of spinal noradrenaline by 6-hydroxydopamine on the development of renal hypertension in rats. | Bosland, MC., et al. 1981. Clin Exp Pharmacol Physiol. 8: 67-77. PMID: 7471522
- Investigation of 6-hydroxydopamine-induced plasma extravasation in rat skin. | Cambridge, H., et al. 1996. Eur J Pharmacol. 301: 151-7. PMID: 8773459
Inhibitor of:
CDNF, and TH.Activator of:
β-synuclein, Bag-2, FEV, LOC100039631, LOC646576, PBR, and UCH-L1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Hydroxydopamine hydrochloride, 100 mg | sc-203482 | 100 mg | $146.00 |