Methacycline Hydrochloride (CAS 3963-95-9)

Methacycline Hydrochloride, with the CAS number 3963-95-9, is a tetracycline antibiotic known for its broad-spectrum antibacterial activity. This compound operates primarily by inhibiting protein synthesis in bacteria. Methacycline Hydrochloride achieves this by binding to the 30S ribosomal subunit, which prevents the attachment of aminoacyl-tRNA to the ribosomal acceptor (A) site during the elongation phase of protein synthesis. As a result, this action blocks the addition of amino acids to the growing peptide chain, effectively halting the production of proteins essential for bacterial growth and survival. In the context of research, Methacycline Hydrochloride has been utilized extensively to study bacterial ribosome function and the mechanisms of action of tetracycline antibiotics. These studies have provided deeper insights into how modifications in the chemical structure of tetracyclines influence their binding affinity and efficacy. Additionally, research involving Methacycline Hydrochloride has contributed significantly to the understanding of bacterial resistance mechanisms. This involves exploring how bacteria alter their ribosomal components to evade the inhibitory effects of antibiotics, thus providing critical information for the design of novel antibacterial agents that can circumvent or overcome existing resistance pathways. This chemical serves as a valuable tool in microbiological and pharmacological studies focused on improving antibacterial strategies.