TGF beta Inhibitors
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibits the TGFβ type I receptor ALK5 kinase activity, which can prevent the phosphorylation of Smad proteins, downstream effectors in the TGFβ signaling pathway. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $65.00 $122.00 $428.00 $851.00 $1873.00 $4994.00 | 33 | |
AEBSF hydrochloride is a potent serine protease inhibitor that selectively disrupts the activity of various proteases involved in TGF-beta signaling pathways. Its unique ability to form stable complexes with target enzymes alters their catalytic efficiency, thereby modulating proteolytic processes. This compound exhibits distinct binding kinetics, allowing for precise control over protease activity, which can significantly influence cellular signaling cascades and downstream biological responses. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
Inhibits the kinase activity of TGFβ type I receptors ALK4, ALK5, and ALK7, which can reduce Smad phosphorylation and signaling. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $88.00 | 3 | |
Targets TGFβ type I receptor kinase, which can lead to decreased TGFβ signaling through the disruption of Smad phosphorylation. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $213.00 $359.00 | 3 | |
Inhibits TGFβ receptor I, potentially reducing Smad2/3 phosphorylation and subsequent transcriptional responses to TGFβ. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
Inhibits ALK5 kinase activity, which can prevent Smad2/3 phosphorylation and thus impair TGFβ signal transduction. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
Blocks ALK4, ALK5, and ALK7 kinase activities, which can attenuate Smad phosphorylation and TGFβ signaling. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $77.00 $153.00 $219.00 $663.00 $1248.00 $4382.00 $7850.00 | 8 | |
Inhibits ALK5 kinase, which can lead to decreased Smad2/3 phosphorylation and downregulation of TGFβ signal transduction. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $102.00 $416.00 | 6 | |
Can modulate TGFβ signaling through downregulation of TGFβ expression, although its precise mechanism of action is not fully elucidated. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $31.00 $103.00 $283.00 $978.00 | 2 | |
Reduces the synthesis and release of TGFβ, which can result in decreased TGFβ signaling. | ||||||