TEX19.2 Inhibitors
TEX19.2 inhibitors encompass a variety of chemical compounds that disrupt specific signaling pathways, indirectly leading to decreased activity or expression of TEX19.2. LY294002 and Wortmannin, both PI3K inhibitors, function to derail the PI3K/Akt signaling cascade, which is crucial for multiple cellular processes such as gene expression and survival. The inhibition of this pathway can result in reduced transcriptional activity, thereby potentially diminishing the expression of TEX19.2 if it is under the control of PI3K/Akt signaling. Similarly, compounds like PD98059, U0126, and PD0325901, all of which are MEK inhibitors, target the MAPK/ERK pathway. By obstructing this pathway, these inhibitors may reduce the transcription of genes, including TEX19.2, assuming it is responsive to MAPK/ERK pathway signals.
Furthermore, the TGF-β receptor kinase inhibitor SB431542 and the BMP signaling blocker Dorsomorphin could alter gene expression profiles that include TEX19.2 by disrupting their respective Smad-dependent pathways. Additional inhibitors target protein synthesis and cytoskeletal dynamics, which can indirectly affect the expression of TEX19.2. Rapamycin and AZD8055 are both mTOR inhibitors, with AZD8055 being capable of suppressing both mTORC1 and mTORC2 complexes, resulting in a comprehensive reduction of protein synthesis that can extend to TEX19.2.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Phosphoinositide 3-kinase (PI3K) inhibitor that prevents Akt phosphorylation. Since Akt can regulate various cellular processes including gene expression, LY294002 may indirectly reduce the expression of TEX19.2 by inhibiting the PI3K/Akt pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that blocks the MAPK/ERK pathway. By inhibiting this pathway, PD98059 can lead to reduced transcription of a variety of genes, potentially including TEX19.2, if the MAPK/ERK pathway is involved in its regulation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β receptor kinase inhibitor that impedes the Smad2/3 signaling pathway. Disruption of this pathway could lead to altered gene expression profiles, potentially decreasing TEX19.2 expression if it is downstream of TGF-β signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor that leads to decreased protein synthesis by inhibiting the mTORC1 complex. This could reduce the overall expression of proteins, including TEX19.2, by general suppression of translation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Another MEK inhibitor that blocks the MAPK/ERK pathway, which could indirectly lead to decreased expression of TEX19.2 by impeding transcriptional regulation via this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor similar to LY294002, which could decrease Akt signaling and subsequently reduce TEX19.2 expression as a result of reduced transcriptional activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that can suppress the JNK signaling pathway. By inhibiting this pathway, SP600125 could potentially decrease the transcriptional activity of genes regulated by JNK, possibly including TEX19.2. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
Inhibitor of BMP signaling which can block Smad1/5/8 phosphorylation. By inhibiting this pathway, Dorsomorphin could reduce the expression of genes downstream of BMP signaling, potentially including TEX19.2. | ||||||
BIX 02189 | 1094614-85-3 | sc-364436 sc-364436A | 5 mg 10 mg | $220.00 $378.00 | 5 | |
MEK5 inhibitor that specifically inhibits the ERK5 pathway. This inhibition could lead to a decrease in transcriptional activity of genes regulated by ERK5, potentially affecting the expression of TEX19.2. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor that interferes with the actin cytoskeleton dynamics. By disrupting actin polymerization, Y-27632 could affect nuclear signaling and gene expression, potentially reducing TEX19.2 expression. | ||||||