Tenrl Activators
Tenrl activators are a group of compounds that serve to increase the functional activity of Tenrl, a protein involved in the cAMP-dependent protein kinase (PKA) pathway. The compounds listed above primarily function by raising intracellular cAMP levels, which subsequently leads to the activation of PKA. Tenrl's role within this PKA pathway means that elevated cAMP levels and subsequent PKA activation enhances its functional activity. The activators include Forskolin, a potent activator of adenylyl cyclase, and 8-Bromo-cAMP, a cell-permeable cAMP analog. Both increase intracellular cAMP levels, leading to PKA activation. IBMX and Rolipram, inhibitors of phosphodiesterase, prevent the breakdown of cAMP, thereby raising intracellular levels and activating PKA.
Others, including Epinephrine, Isoproterenol, Dopamine, Histamine, Salbutamol, Prostaglandin E2 (PGE2), Glucagon, and Terbutaline function as receptor agonists. They bind to their respective receptors, leading to increased intracellular cAMP levels, which subsequently leads to PKA activation and enhanced Tenrl activity. These compounds, despite having different mechanisms of action, all lead to increased activation of Tenrl, demonstrating the protein's integration within various biochemical pathways. The elevated cAMP levels triggered by these compounds activate PKA, thereby enhancing the functional activityof Tenrl within the PKA pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent activator of adenylyl cyclase, leading to increased intracellular cAMP levels. Tenrl is part of the cAMP-dependent protein kinase (PKA) pathway, and is activated by elevated cAMP levels, enhancing Tenrl's functional activity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog. It enhances Tenrl's functional activity by increasing intracellular cAMP levels, leading to activation of the PKA pathway, in which Tenrl plays a role. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor, preventing the breakdown of cAMP and leading to higher intracellular cAMP levels. This activates the PKA pathway, where Tenrl is situated, and enhances Tenrl's functional activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor. It increases intracellular cAMP levels, leading to PKA activation and thus enhancing the functional activity of Tenrl within the PKA pathway. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to adrenergic receptors, leading to increased cAMP levels and subsequent PKA activation. This enhances Tenrl's functional activity as Tenrl is a part of this PKA pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta adrenergic receptor agonist which can increase intracellular cAMP levels, leading to PKA activation. This enhances the functional activity of Tenrl within the PKA pathway. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to D1-like dopamine receptors, increasing intracellular cAMP levels and subsequent PKA activation. This enhances Tenrl's functional activity as Tenrl is a part of this PKA pathway. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its action on H2 receptors, increases intracellular cAMP levels, leading to PKA activation. This enhances Tenrl's functional activity as Tenrl is a part of this PKA pathway. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol is a selective beta-2 adrenergic receptor agonist that increases intracellular cAMP levels, leading to PKA activation. This enhances the functional activity of Tenrl within the PKA pathway. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) increases intracellular cAMP levels through its action on EP receptors, leading to PKA activation. This enhances the functional activity of Tenrl within the PKA pathway. | ||||||