TDRD7 Activators
TDRD7 activators are a class of compounds that indirectly enhance the functional activity of TDRD7 through specific cellular pathways. The compounds listed above primarily function by increasing intracellular cAMP levels, which subsequently leads to activation of cAMP-dependent protein kinase (PKA). PKA can indirectly affect the activity of TDRD7 within its pathway, enhancing its functional activity. The increased cAMP levels, catalyzed by these compounds, can activate PKA, thereby indirectly enhancing the functional activity of TDRD7.
These activators include Forskolin, a potent activator of adenylyl cyclase, and 8-Bromo-cAMP, a cell-permeable cAMP analog. Both increase intracellular cAMP levels, leading to PKA activation. Similarly, inhibitors of phosphodiesterase, such as IBMX and Rolipram, prevent the breakdown of cAMP, leading to higher intracellular levels and subsequent PKA activation. Other activators, including Epinephrine, Isoproterenol, Dopamine, Histamine, Salbutamol, Prostaglandin E2 (PGE2), Glucagon, and Terbutaline,function as receptor agonists. They bind to their respective receptors and increase intracellular cAMP levels, which subsequently leads to PKA activation and the indirect enhancement of TDRD7 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent activator of adenylyl cyclase, leading to increased intracellular cAMP levels. TDRD7, as a part of the cAMP-dependent protein kinase (PKA) pathway, can be indirectly activated by increased cAMP levels, thereby enhancing the functional activity of TDRD7. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog. It acts similarly to forskolin by increasing the intracellular cAMP level and triggering PKA, which can indirectly enhance the functional activity of TDRD7 within the PKA pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor, preventing the breakdown of cAMP and thus leading to higher intracellular cAMP levels. This subsequently activates PKA, which can indirectly enhance the functional activity of TDRD7 within the PKA pathway. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor that increases intracellular cAMP levels, leading to PKA activation. This can indirectly enhance the functional activity of TDRD7 within the PKA pathway. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is a hormone and neurotransmitter that binds to adrenergic receptors, leading to increased cAMP levels and subsequent PKA activation. This can indirectly enhance the functional activity of TDRD7 within the PKA pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta adrenergic receptor agonist which can increase intracellular cAMP levels, leading to PKA activation. This can indirectly enhance the functional activity of TDRD7 within the PKA pathway. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine is a neurotransmitter that can bind to D1-like dopamine receptors, increasing intracellular cAMP levels and subsequent PKA activation. This can indirectly enhance the functional activity of TDRD7 within the PKA pathway. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its action on H2 receptors, increases intracellular cAMP levels, leading to PKA activation. This can indirectly enhance the functional activity of TDRD7 within the PKA pathway. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol is a selective beta-2 adrenergic receptor agonist that increases intracellular cAMP levels, leading to PKA activation. This can indirectly enhance the functional activity of TDRD7 within the PKA pathway. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) increases intracellular cAMP levels through its action on EP receptors, leading to PKA activation. This can indirectly enhance the functional activity of TDRD7 within the PKA pathway. | ||||||