TDRD7 Activators

TDRD7 activators are a class of compounds that indirectly enhance the functional activity of TDRD7 through specific cellular pathways. The compounds listed above primarily function by increasing intracellular cAMP levels, which subsequently leads to activation of cAMP-dependent protein kinase (PKA). PKA can indirectly affect the activity of TDRD7 within its pathway, enhancing its functional activity. The increased cAMP levels, catalyzed by these compounds, can activate PKA, thereby indirectly enhancing the functional activity of TDRD7.

These activators include Forskolin, a potent activator of adenylyl cyclase, and 8-Bromo-cAMP, a cell-permeable cAMP analog. Both increase intracellular cAMP levels, leading to PKA activation. Similarly, inhibitors of phosphodiesterase, such as IBMX and Rolipram, prevent the breakdown of cAMP, leading to higher intracellular levels and subsequent PKA activation. Other activators, including Epinephrine, Isoproterenol, Dopamine, Histamine, Salbutamol, Prostaglandin E2 (PGE2), Glucagon, and Terbutaline,function as receptor agonists. They bind to their respective receptors and increase intracellular cAMP levels, which subsequently leads to PKA activation and the indirect enhancement of TDRD7 activity.