TDRD5 Inhibitors
TDRD5 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the TDRD5 protein, a member of the Tudor domain-containing family. TDRD5 is primarily involved in the regulation of germ cell development and RNA processing within specialized cellular structures called germ granules. These granules are crucial for the proper management and processing of RNA molecules during spermatogenesis, where TDRD5 plays a key role in maintaining the integrity and function of these granules. TDRD5 interacts with small RNA pathways and is important for the regulation of RNA silencing, ensuring the precise control of gene expression during the formation of sperm cells. Inhibiting TDRD5 disrupts its ability to interact with other proteins and RNAs, leading to alterations in the organization and function of germ granules.
The study of TDRD5 inhibitors provides valuable insights into the molecular mechanisms that govern RNA processing and the formation of germ cells. By inhibiting TDRD5, researchers can explore the effects of disrupted RNA regulation on the development of germ cells, revealing the role this protein plays in cellular differentiation and gene silencing processes. These inhibitors also aid in understanding how Tudor domain-containing proteins contribute to the organization of cellular structures and the broader landscape of RNA-protein interactions. Investigating the impact of TDRD5 inhibition sheds light on the importance of RNA granules in the post-transcriptional regulation of gene expression, particularly within the context of reproductive biology. As a result, TDRD5 inhibitors represent key tools for studying the intricate molecular dynamics of RNA regulation in germ cells and their role in developmental processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $35.00 $86.00 $216.00 $427.00 | 8 | |
DNA synthesis inhibitor. As TDRD5 has roles in RNA biogenesis, affecting DNA synthesis can indirectly influence the overall RNA generation process, thereby modulating proteins involved in these processes, including TDRD5. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methylation inhibitor. Altering DNA methylation can have ripple effects on RNA synthesis and processing, potentially affecting TDRD5 functionality in the piRNA biogenesis pathway. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Transcription inhibitor. By halting the transcription process, it affects the downstream RNA processes and can indirectly modulate proteins like TDRD5 that play roles in RNA-related pathways. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
RNA polymerase II inhibitor. Directly impacts transcription, which indirectly affects RNA biogenesis pathways and proteins associated with them, like TDRD5. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
CDK9 and RNA polymerase II inhibitor. By inhibiting these key transcription components, RNA processing can be impacted, indirectly affecting TDRD5. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $81.00 | 5 | |
Pyrimidine synthesis inhibitor. By impacting pyrimidine synthesis, RNA synthesis can be indirectly affected, which can modulate the functionality of proteins like TDRD5 involved in RNA-related pathways. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Inosine monophosphate dehydrogenase (IMPDH) inhibitor. IMPDH is involved in guanine nucleotide synthesis; thus, its inhibition can affect RNA synthesis, potentially influencing TDRD5 functionality. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
Guanosine analogue that inhibits IMPDH. Like Mycophenolic acid, it affects guanine nucleotide synthesis, potentially influencing RNA-related processes and proteins like TDRD5. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
Purine analogue that affects DNA and RNA synthesis. Given TDRD5's role in RNA biogenesis, modulating these pathways can indirectly affect its functionality. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $99.00 | 5 | |
Adenosine analogue inhibiting RNA synthesis. By directly impacting RNA synthesis, it can have an indirect effect on proteins involved in RNA biogenesis, like TDRD5. | ||||||