TDRD5 Activators
TDRD5 activators encompass a group of chemical entities designed to selectively increase the activity of the Tudor Domain Containing 5 (TDRD5) protein. TDRD5 is part of a larger family of Tudor domain-containing proteins that are characterized by the presence of one or more Tudor domains, which typically mediate protein-protein interactions that are essential for various cellular processes. The activators target TDRD5 with the intent to modulate its role within the cell, often through direct binding to the protein, which may enhance its natural interactions or promote its stabilization within the cellular milieu. These interactions are complex and often involve nuanced changes to the protein's conformation or its affinity for interacting with other molecular partners, such as RNA or chromatin. The activity of TDRD5 is linked to its participation in the intricate networks of intracellular signaling and regulation of gene expression. By influencing TDRD5 activity, its activators can affect the downstream processes that are governed by the protein.
Chemically, TDRD5 activators are a diverse set of molecules that can exhibit a wide range of structures and properties. The development of these activators typically begins with an in-depth analysis of the TDRD5 protein's structure, particularly the Tudor domains, to identify potential binding sites for small molecule activators. Advanced computational methods, such as molecular modeling and docking simulations, play a pivotal role in predicting how these potential activators might interact with TDRD5, and which molecular configurations could result in the most effective activation. Synthetic chemists then use this information to craft molecules that can precisely fit within these binding sites, often employing a variety of functional groups that can form favorable interactions with the protein's surface.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that promotes hyperacetylation of histones, causing chromatin to adopt a more relaxed structure which can facilitate increased gene expression. This might enhance the transcription of genes like TDRD5 involved in epigenetic regulation. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
A methyl donor used in various methylation reactions within the cell. It can influence epigenetic marks and subsequently gene expression profiles, which may include TDRD5. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A DNA methyltransferase inhibitor similar to 5-Azacytidine, this compound incorporates into DNA and leads to demethylation effects that can indirectly affect TDRD5 expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
An antitumor antibiotic that can bind to DNA and affect transcription factor binding, potentially modifying the expression of genes including those involved in piRNA pathways where TDRD5 has a role. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor, which may alter the methylation status of genes and impact their expression, including that of TDRD5. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
An inhibitor of acetaldehyde dehydrogenase, but it can also modulate copper distribution in the cell, which could affect various biochemical pathways including those that might influence TDRD5 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of vitamin A that acts as a ligand for retinoic acid receptors influencing gene expression. It can modulate the expression of various genes and might impact the pathways or the expression levels of proteins such as TDRD5. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An activator of adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) and activation of protein kinase A (PKA), which can affect a multitude of signaling pathways and potentially the expression or activity of proteins like TDRD5. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
A sesquiterpene lactone that can inhibit NF-κB, a factor involved in many cellular processes including inflammation and apoptosis. Through these pathways, it may indirectly affect the function or expression of TDRD5. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A short-chain fatty acid and histone deacetylase inhibitor that can alter chromatin structure and gene expression. Its role in epigenetic regulation might lead to changes in the expression of TDRD5. | ||||||