TDRD10 Activators
TDRD10 activators are a class of compounds that indirectly enhance the functional activity of TDRD10 through specific cellular pathways. The compounds listed above primarily function by increasing intracellular cAMP levels, which subsequently leads to activation of cAMP-dependent protein kinase (PKA). PKA can indirectly affect the activity of TDRD10 within the PIWI-interacting RNA (piRNA) pathway, a critical pathway for maintaining genome integrity in germ cells. The increased cAMP levels, catalyzed by these compounds, can activate PKA, thereby indirectly enhancing the functional activity of TDRD10.
These activators include Forskolin, a potent activator of adenylyl cyclase, and 8-Bromo-cAMP, a cell-permeable cAMP analog. Both increase intracellular cAMP levels, leading to PKA activation. Similarly, inhibitors of phosphodiesterase, such as IBMX and Rolipram, prevent the breakdown of cAMP, leading to higher intracellular levels and subsequent PKA activation. Other activators, including Epinephrine, Isoproterenol,Dopamine, Histamine, Salbutamol, Prostaglandin E2 (PGE2), Glucagon, and Terbutaline, function through interaction with specific receptors. These interactions trigger an increase in cAMP levels and subsequent PKA activation. For instance, Epinephrine and Isoproterenol, acting as adrenergic receptor agonists, and Dopamine, acting on D1-like dopamine receptors, all increase intracellular cAMP levels. Similarly, Histamine and PGE2, interacting with H2 and EP receptors respectively, and Salbutamol, Terbutaline, and Glucagon, acting as selective beta-2 adrenergic receptor agonists, also stimulate the increase in intracellular cAMP levels. This cascade of events leads to PKA activation, which can indirectly enhance the functional activity of TDRD10 within the piRNA pathway.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent activator of adenylyl cyclase, leading to increased intracellular cAMP levels. TDRD10, as a part of the PIWI-interacting RNA (piRNA) pathway, can be indirectly activated by cAMP-dependent protein kinase (PKA). Therefore, forskolin can indirectly enhance the functional activity of TDRD10 by increasing cAMP and subsequently activating PKA. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog. It acts similarly to forskolin by increasing the intracellular cAMP level and triggering PKA, which can indirectly enhance the functional activity of TDRD10 within the piRNA pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor, preventing the breakdown of cAMP and thus leading to higher intracellular cAMP levels. This subsequently activates PKA, which can indirectly enhance the functional activity of TDRD10 within the piRNA pathway. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor that increases intracellular cAMP levels, leading to PKA activation. This can indirectly enhance the functional activity of TDRD10 within the piRNA pathway. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is a hormone and neurotransmitter that binds to adrenergic receptors, leading to increased cAMP levels and subsequent PKA activation. This can indirectly enhance the functional activity of TDRD10 within the piRNA pathway. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a non-selective beta adrenergic receptor agonist which can increase intracellular cAMP levels, leading to PKA activation. This can indirectly enhance the functional activity of TDRD10 within the piRNA pathway. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine is a neurotransmitter that can bind to D1-like dopamine receptors, increasing intracellular cAMP levels and subsequent PKA activation. This can indirectly enhance the functional activity of TDRD10 within the piRNA pathway. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its action on H2 receptors, increases intracellular cAMP levels, leading to PKA activation. This can indirectly enhance the functional activity of TDRD10 within the piRNA pathway. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol is a selective beta-2 adrenergic receptor agonist that increases intracellular cAMP levels, leading to PKA activation. This can indirectly enhance the functional activity of TDRD10 within the piRNA pathway. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) increases intracellular cAMP levels through its action on EP receptors, leading to PKA activation. This can indirectly enhance the functional activity of TDRD10 within the piRNA pathway. | ||||||