Tctex1L Inhibitors
Tctex1L Inhibitors serve to regulate or disrupt the functions of Tctex1L, a protein that is a non-catalytic accessory component of the cytoplasmic dynein 1 complex. This complex is crucial for intracellular retrograde motility of vesicles and organelles along microtubules. These chemicals can act by various means, such as destabilizing microtubules, inhibiting kinesin, or affecting ATPase activities, to disrupt the function of Tctex1L. Some inhibitors like Roscovitine target cyclin-dependent kinases, thereby affecting Tctex1L's role in cell cycle progression.
Given the multifaceted role of Tctex1L in both dynein complex formation and cell cycle progression, it is critical that the inhibitory chemicals have a specific mode of action to efficiently regulate Tctex1L. Chemicals like Wortmannin and LY294002 focus on inhibiting PI3K, a key component in intracellular signaling, to potentially disrupt Tctex1L's activities. On the other hand, Okadaic Acid and Methotrexate can specifically affect the protein's role in cell cycle progression. The varying mechanisms by which these chemicals act offer multiple avenues for the specific inhibition of Tctex1L.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole destabilizes microtubules, which can impair the transport cargo function of Tctex1L in the dynein complex. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules, potentially inhibiting Tctex1L's role in cytoplasmic dynein 1 complex formation and its mitotic functions. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol inhibits kinesin, and can indirectly inhibit Tctex1L by affecting the balance of motor proteins along microtubules. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine inhibits cyclin-dependent kinases and can disrupt Tctex1L's role in the progression through mitosis. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-Glucose inhibits glycolysis, thereby affecting cellular energy levels that are essential for Tctex1L’s motor functions. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule assembly, potentially inhibiting Tctex1L's role in dynein complex formation. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and inhibits its polymerization, affecting Tctex1L's role in vesicle and organelle transport. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin inhibits PI3K, affecting intracellular signaling that may regulate Tctex1L's role in dynein complex formation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 inhibits PI3K and can disrupt signaling pathways that may be essential for Tctex1L’s functioning. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases, which can affect Tctex1L’s role in cell cycle progression. | ||||||