TCEAL2 Activators
Activation of TCEAL2, a transcription elongation factor, can be influenced by various chemical compounds that impact intracellular signaling pathways. Compounds that stimulate adenylyl cyclase or inhibit phosphodiesterase activity lead to an increase in cyclic AMP (cAMP) levels within the cell. This elevation in cAMP activates protein kinase A (PKA), which can then phosphorylate substrates that are involved in enhancing transcription elongation, potentially creating a favorable environment for TCEAL2 activity. Similarly, compounds that act as agonists for receptors coupled to the Gs protein would also trigger this cAMP-mediated signaling cascade. Once activated, these receptors stimulate the production of cAMP, further propagating the signaling events that can positively influence transcription elongation facilitated by TCEAL2. The role of TCEAL2 in transcription elongation is thus indirectly supported by these chemical compounds through their ability to modulate specific signaling pathways that increase the transcriptional capacity of the cell.
Additionally, various agents that serve as analogs of cAMP or are competitive inhibitors of enzymes that degrade cAMP and cGMP contribute to the maintenance of high intracellular levels of these cyclic nucleotides. Elevated cAMP and cGMP levels can prolong the activation state of PKA, resulting in continued phosphorylation activity. This sustained signaling can indirectly aid in the activation of transcription elongation mechanisms in which TCEAL2 is involved. Furthermore, molecules that interact with adrenergic receptors to elevate cAMP levels can indirectly support the function of TCEAL2 in transcription elongation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Directly stimulates adenylyl cyclase, increasing cAMP levels in cells. Elevated cAMP can enhance transcription elongation processes, thereby potentially upregulating TCEAL2 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to sustained signaling that can promote TCEAL2 function in transcription elongation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Selective phosphodiesterase-4 inhibitor, increasing cAMP levels. This can contribute to the activation of PKA and subsequent phosphorylation events that may positively influence TCEAL2 activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Activates adrenergic receptors which can increase intracellular cAMP levels, potentially augmenting TCEAL2 function by enhancing transcription elongation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Binds to its receptors, leading to increased cAMP production. This signaling can indirectly facilitate transcriptional elongation, potentially elevating the activity of TCEAL2. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Through its action on H2 receptors, can increase cAMP levels in certain cell types, indirectly supporting TCEAL2's role in transcription elongation by altering transcriptional dynamics. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
A competitive inhibitor of phosphodiesterases, leading to increased cAMP levels which may indirectly boost TCEAL2 activity by promoting transcription elongation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that activates PKA and can increase phosphorylation events, potentially leading to an environment that supports TCEAL2 activity in transcription elongation. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
A dual-selective phosphodiesterase 3/4 inhibitor, enhancing cAMP levels and possibly facilitating TCEAL2's role in transcription elongation. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $147.00 | ||
Inhibits phosphodiesterase 3, leading to increased cAMP levels and could thereby indirectly support TCEAL2 function in transcription elongation. | ||||||