TCEAL2 Inhibitors
TCEAL2 inhibitors incorporate a variety of chemical entities that interfere with the functional activity of TCEAL2, a protein implicated in the regulation of transcription processes. These inhibitors act through diverse mechanisms to modulate cellular pathways that indirectly affect TCEAL2's role. Certain inhibitors obstruct cell cycle-dependent kinases, leading to an arrest in the cell cycle, which subsequently disrupts the transcription cycle where TCEAL2 is active. Others target key signaling pathways such as the phosphoinositide 3-kinase (PI3K) pathway or the mitogen-activated protein kinase (MAPK) pathway, which are vital for transcriptional regulation. Inhibition of these pathways results in decreased phosphorylation and activity of downstream transcription factors and regulators, thereby dampening the transcriptional events and elongation processes involving TCEAL2.
Additionally, compounds that inhibit histone deacetylases or DNA methyltransferases alter the epigenetic landscape, affecting chromatin structure and gene expression profiles, which can lead to a repressive environment for genes that TCEAL2 may target. Inhibitors of the mTOR signaling pathway can downregulate transcriptional programs that engage TCEAL2, while ion channel modulators such as chloride channel activators can perturb cellular signaling, indirectly influencing transcriptional mechanisms where TCEAL2 is implicated. Furthermore, inhibitors that target the stability and function of transcription factors, or directly inhibit the catalytic activity of RNA polymerase II, reduce the overall transcriptional output, thereby indirectly suppressing TCEAL2's function in transcription elongation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a potent cyclin-dependent kinase (CDK) inhibitor, which affects cell cycle regulation. By inhibiting CDKs, it can lead to cell cycle arrest, thereby indirectly decreasing the activity of TCEAL2 by preventing the progression of the transcription cycle where TCEAL2 functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor. PI3K signaling is crucial for many cellular functions, including transcription. Inhibition of PI3K can lead to reduced phosphorylation and activation of downstream targets, which would indirectly suppress TCEAL2 activity by limiting the transcriptional processes it is involved with. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2 which are upstream of ERK in the MAPK pathway. Since TCEAL2 is associated with transcription regulation, and MAPK pathway influences transcription factors, inhibiting MEK could result in decreased TCEAL2 functional activity due to reduced transcription factor activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor that affects chromatin remodeling and gene expression. It can lead to hyperacetylation of histones, hence altering transcription. This can indirectly inhibit TCEAL2 activity by changing the transcriptional landscape and potentially repressing genes that require TCEAL2 for their elongation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can lead to the demethylation and activation of silenced genes. This can indirectly inhibit TCEAL2 by altering the transcriptional program of the cell, potentially affecting genes that regulate the function or expression of TCEAL2. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor and by inhibiting tyrosine kinases, it can reduce phosphorylation of downstream proteins that control transcription, indirectly inhibiting TCEAL2 by limiting transcriptional events where TCEAL2 might be involved. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase, preventing RNA synthesis. This will indirectly inhibit TCEAL2 by halting the transcription process where TCEAL2 participates in elongating transcripts. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, which can have broad effects on cellular growth and metabolism. Inhibition of mTOR can downregulate transcriptional programs that may involve TCEAL2, thus indirectly inhibiting its functional activity. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $56.00 $75.00 | 2 | |
Ivermectin activates chloride channels, which can lead to hyperpolarization of cells and perturbation of signaling. This ion channel modulation can indirectly inhibit TCEAL2 by altering cell states and potentially affecting transcriptional processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which is involved in the MAPK/ERK pathway. By inhibiting MEK, PD 98059 can decrease ERK pathway signaling, thus indirectly inhibiting TCEAL2 by reducing the activity of transcription factors and transcriptional regulators. | ||||||