Actinomycin D CAS: 50-76-0
MF: C62H86N12O16
MW: 1255.42
A potent antibiotic that binds to the GpC steps of DNA.

Actinomycin D (CAS 50-76-0)

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Sinónimo: Oncostatin K; Actinomycin IV
Solicitud: A potent antibiotic that binds to the GpC steps of DNA
Número de CAS: 50-76-0
Pureza: ≥98%
Peso Molecular: 1255.42
Fórmula Molecular: C62H86N12O16
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Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive bacteria than gram negative bacteria. Actinomycin D can induce apoptosis in several cell lines such as lung and prostate cancer lines, and human blood lymphocytes, among others. This compound is also an RNA polymerase inhibitor. In studies it has been observed that Actinomycin D elevates p53 expression, leading to the increase of PUMAα/β (the p53 upregulated modulator of apoptosis protein; PUMA), and can also induce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced caspase-dependent and -independent apoptosis.


References

1. Bailey, S.A., et al. 1993. Biochemistry. 32: 5881-5887. PMID: 8504108
2. Verhaegen, S., et al. 1995. Biochem. Pharmacol. 50: 1021-1029. PMID: 7575657
3. Kalousek, I., et al. 2007. Anticancer Drugs. 18: 763-772. PMID: 17581298
4. Wang, M.J., et al. 2007. Neurosci. Res. 59: 40-46. PMID: 17707539
5. Xu, H. and Krystal, G.W. 2010. Clin Cancer Res. PMID: 20732961

Estado de Materia :
Solid
Forma Derivada :
Streptomyces parvulus
Solubilidad :
Soluble in DMSO (>20 mg/ml), 100% ethanol (1 mg/ml), methanol, chloroform, acetonitrile (9.80 - 10.20 mg/ml), and 1,2-Propanediol.
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
251-253° C
Punto de ebullición :
1386.05° C at 760 mmHg (Predicted)
Densidad :
1.43 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.66 (Predicted)
Actividad Óptica :
α28/D -315°, c = 0.25 in methanol
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
RTECS :
AU1575000
PubChem CID :
2019
Indice de Merck :
14: 2800
Número MDL :
MFCD00005033
Número EC :
200-063-6
Registro Beilstein :
605235
SMILES :
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C

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Actinomycin D  Menciones del Producto

Ver como otros han utilizado Actinomycin D. Haga click en la entrada de PubMed .

Citaciones 1 a 10 de un total de 23

PMID: # 31222373  Luo, Y. et al. 2019. Cell. Mol. Life Sci.

PMID: # 30870073  Song, H.|Feng, X.|Zhang, H.|Luo, Y.|Huang, J.|Lin, M.|Jin, J.|Ding, X.|Wu, S.|Huang, H.|Yu, T.|Zhang, M.|Hong, H.|Yao, S.|Zhao, Y.|Zhang, Z.| et al. 2019. Autophagy. 15: 1419-1437.

PMID: # 30796352  Yang, F.|Jin, H.|Que, B.|Chao, Y.|Zhang, H.|Ying, X.|Zhou, Z.|Yuan, Z.|Su, J.|Wu, B.|Zhang, W.|Qi, D.|Chen, D.|Min, W.|Lin, S.|Ji, W.| et al. 2019. Oncogene. 38: 4755-4772.

PMID: # 30639474  Liu, Y.|Wei, W.|Hong, C.|Wang, Y.|Sun, X.|Ma, J.|Zheng, F.| et al. 2019. Mol. Immunol. 107: 10-20.

PMID: # 30821592  Peng, M.|Wang, J.|Tian, Z.|Zhang, D.|Jin, H.|Liu, C.|Xu, J.|Li, J.|Hua, X.|Xu, J.|Huang, C.|Huang, C.| et al. 2019. Autophagy.

PMID: # 31119302  Liu, Y.|Wei, W.|Wang, Y.|Wan, C.|Bai, Y.|Sun, X.|Ma, J.|Zheng, F.| et al. 2019. Inflamm. Res. 68: 597-611.

PMID: # 30873168  Figliuolo da Paz, V.|Jamwal, DR.|Gurney, M.|Midura-Kiela, M.|Harrison, CA.|Cox, C.|Wilson, JM.|Ghishan, FK.|Kiela, PR.| et al. 2019. Front Immunol. 10: 304.

PMID: # 30602711  Weiss, J.| et al. 2018. Molecules. 24:

PMID: # 30414569  Shu, Y.|Wu, K.|Zeng, Z.|Huang, S.|Ji, X.|Yuan, C.|Zhang, L.|Liu, W.|Huang, B.|Feng, Y.|Zhang, B.|Dai, Z.|Shen, Y.|Luo, W.|Wang, X.|Liu, B.|Lei, Y.|Ye, Z.|Zhao, L.|Cao, D.|Yang, L.|Chen, X.|Luu, HH.|Reid, RR.|Wolf, JM.|Lee, MJ.|He, TC.| et al. 2018. Mol Ther Nucleic Acids. 13: 556-567.

PMID: # 29684377  Tocchetti, GN. et al. 2018. Biochem. Pharmacol. 154: 118-126.

Citaciones 1 a 10 de un total de 23
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