TBPIP Inhibitors
TBPIP Inhibitors are a group of chemical compounds that primarily target the DNA damage response pathway and the PI3K/Akt signaling pathway, both of which TBPIP is directly involved in. Inhibitors that disrupt the structure and function of the Golgi apparatus, such as Brefeldin A, or inhibit the transport of vesicles to the plasma membrane, such as Exo2, can impede the trafficking of TBPIP to the nucleus, thereby leading to its functional inhibition in mediating DNA repair and homologous recombination. Similarly, topoisomerase II inhibitors, such as Mitoxantrone and Etoposide, cause DNA damage, thereby overactivating the DNA damage response pathway in which TBPIP is involved. This overactivation can disrupt TBPIP's role in DNA repair, leading to its functional inhibition.
On the other hand, tyrosine kinase inhibitors such as Genistein and Staurosporine can interfere with phosphorylation processes necessary for TBPIP's function, thereby leading to its functional inhibition. Inhibitors of PI3K and mTOR, such as LY294002, Wortmannin, and Rapamycin, can indirectly affect TBPIP's function in DNA repairand homologous recombination by inhibiting these key proteins in the PI3K/Akt pathway. Another class of TBPIP inhibitors includes those that inhibit phospholipase C (PLC) and protein tyrosine phosphatases, such as U73122 and Pervanadate, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus, thereby impeding the trafficking of TBPIP to the nucleus. This can lead to the decreased functional activity of TBPIP in mediating DNA repair and homologous recombination. | ||||||
Exo2 | 304684-77-3 | sc-215011 sc-215011A | 5 mg 25 mg | $89.00 $288.00 | 1 | |
Exo2 is an inhibitor of the exocyst complex, which is involved in the transport of vesicles to the plasma membrane. It can reduce the function of this pathway, thus indirectly inhibiting the functional activity of TBPIP in the DNA repair process. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Mitoxantrone is a topoisomerase II inhibitor that can cause DNA damage, thereby activating the DNA damage response pathway in which TBPIP is involved. The overactivation of this pathway can disrupt TBPIP's role in DNA repair. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that causes DNA damage and triggers the DNA damage response pathway. Overactivation of this pathway can disrupt TBPIP's role in DNA repair and homologous recombination. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can interfere with phosphorylation processes necessary for TBPIP's function in DNA repair and homologous recombination. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases and can interfere with phosphorylation processes necessary for TBPIP's function in DNA repair and homologous recombination. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of PI3K, a key enzyme in the PI3K/Akt pathway. By inhibiting PI3K, it can indirectly affect TBPIP’s function in DNA repair and homologous recombination. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a key protein in the PI3K/Akt pathway. By inhibiting mTOR, it can indirectly affect TBPIP’s function in DNA repair and homologous recombination. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent, irreversible inhibitor of PI3K, a key enzyme in the PI3K/Akt pathway. Through this, it can indirectly inhibit TBPIP, which is involved in DNA repair and homologous recombination. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms. While it does not inhibit transcription or translation of TBPIP, it can indirectly affect the replenishment of TBPIP levels, thus affecting its function in DNA repair and homologous recombination. | ||||||