TBC1D3G Activators
TBC1D3G, a member of the TBC1 domain family, plays a critical role in regulating intracellular vesicle trafficking and membrane dynamics. As a GTPase-activating protein (GAP), TBC1D3G acts on Rab GTPases, which are key regulators of vesicle transport processes within cells. By promoting the hydrolysis of GTP to GDP, TBC1D3G modulates the activity of Rab GTPases, thereby regulating various steps of vesicle trafficking, including vesicle budding, transport, and fusion with target membranes. Through its regulatory role in these processes, TBC1D3G contributes to the maintenance of cellular homeostasis and the proper functioning of organelles and cellular compartments.
Activation of TBC1D3G can occur through several mechanisms that enhance its GAP activity and promote its involvement in vesicle trafficking pathways. One potential mechanism involves post-translational modifications, such as phosphorylation, acetylation, or ubiquitination, which may regulate TBC1D3G activity and localization within the cell. These modifications can alter the conformation of TBC1D3G or its interaction with binding partners, leading to enhanced GAP activity towards Rab GTPases. Additionally, signaling pathways activated by cellular stimuli, such as growth factors or stress signals, can regulate TBC1D3G expression or activity. Activation of upstream kinases or signaling cascades can lead to the phosphorylation or activation of TBC1D3G, thereby increasing its GAP activity and promoting the efficient regulation of vesicle trafficking processes. Overall, elucidating the mechanisms of TBC1D3G activation provides insights into its role in cellular physiology and may uncover potential targets for interventions aimed at modulating intracellular vesicle dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to the phosphorylation of downstream effectors that interact with TBC1D3G, potentially enhancing its GTPase-activating protein (GAP) activity towards specific targets such as the Ras family of proteins. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, leading to activation of the Wnt/β-catenin pathway. TBC1D3G may be indirectly activated as part of the response to increased Wnt signaling, which could involve regulation of GTPases in this pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels, leading to activation of PKA. PKA phosphorylation of targets could enhance TBC1D3G activity by influencing GTPase signaling pathways in which TBC1D3G is involved. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calmodulin-dependent kinase (CaMK) pathways. These pathways can intersect with those regulated by TBC1D3G, potentially enhancing its GAP activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the insulin receptor, triggering the PI3K/Akt pathway. TBC1D3G may be indirectly activated through this pathway as it could interact with proteins regulated by PI3K/Akt signaling, altering its functional activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation of cellular proteins. This hyperphosphorylated state could enhance TBC1D3G activity by modulating the GTPase signaling network. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a β-adrenergic agonist that increases cAMP levels, which could lead to the activation of PKA. PKA, in turn, could phosphorylate substrates that modulate TBC1D3G activity in GTPase signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a JNK activator that can influence the MAPK pathway, potentially enhancing TBC1D3G activity by modulating its interaction with GTPase signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is an MEK inhibitor which, through the reduction of ERK phosphorylation, could affect signaling pathways that intersect with those modulated by TBC1D3G, potentially enhancing its functional activity. | ||||||