TBC1D13 Activators
TBC1D13 activators typically function through modulation of pathways that affect endosomal sorting and trafficking, emphasizing the protein's GAP activity for cellular homeostasis. For example, Wortmannin and LY294002, as PI3K inhibitors, block a pathway crucial for endosomal maturation, thereby making TBC1D13's role more vital in the cellular trafficking system. This type of chemical interference thus results in increased demand for TBC1D13's role in routing endosomal cargoes.
Similarly, agents like U0126 and Dynasore, by inhibiting MEK1/2 and Dynamin respectively, disrupt endosomal sorting pathways and thus necessitate the role of TBC1D13 in such processes. Bafilomycin A1 and EIPA, which interfere with endosomal acidification, also highlight the importance of TBC1D13 in sorting and trafficking operations. Chloroquine, by affecting endosomal pH, necessitates TBC1D13's involvement in trafficking, as do 3-MA and Rapamycin by their influence on autophagy and mTOR signaling respectively. Pitstop 2 and Alsterpaullone add further layers of complexity by affecting endocytosis and cell cycle, respectively, thereby broadening the role of TBC1D13 in cellular trafficking.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor that hampers endosomal trafficking, thereby indirectly increasing the requirement for TBC1D13's GAP activity. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynamin inhibitor that affects endocytosis, requiring TBC1D13 for subsequent endosomal processing. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
V-ATPase inhibitor that hampers endosomal acidification, making TBC1D13’s role in endosomal sorting more necessary. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K, thus affecting endosomal sorting and increasing reliance on TBC1D13. | ||||||
5-(N-Ethyl-N-isopropyl)-Amiloride | 1154-25-2 | sc-202458 | 5 mg | $104.00 | 20 | |
Na+/H+ exchanger inhibitor that influences endosomal pH, indirectly affecting TBC1D13’s role in endosomal sorting. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Lysosomotropic agent that affects endosomal pH, making TBC1D13's role in endosomal trafficking more critical. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor that affects cellular trafficking pathways, increasing the need for TBC1D13's GAP activity. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
Autophagy inhibitor, affecting vesicular sorting and thus requiring TBC1D13 for endosomal management. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
PKC inhibitor, affects endocytosis and increases dependence on TBC1D13 for endosomal sorting. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Clathrin inhibitor, impeding endocytosis, thus making TBC1D13 more vital for endosomal management. | ||||||