TAP2 Activators
TAP2 Activators represent a group of chemical compounds that enhance the activity of Transporter associated with Antigen Processing 2 (TAP2), playing a pivotal role in the immune system's antigen presentation mechanism. These activators, through their various actions, ensure the efficient functioning of TAP2. Zinc(II) Chloride, for example, directly influences TAP2 by stabilizing the TAP1/TAP2 complex, leading to an increased affinity for peptide substrates. This enhanced binding is critical for effective antigen processing, as TAP2 is responsible for translocating peptides into the endoplasmic reticulum for MHC class I molecule loading.
Further, other activators like Sodium Fluoride and Leupeptin indirectly bolster TAP2's role by maintaining a phosphorylation state conducive to its activity and inhibiting proteolytic enzymes, respectively, resulting in a surplus of peptides for TAP2 transport. Inhibitors of the proteasome, such as MG132, Epoxomicin, and Lactacystin, indirectly aid in TAP2 activation by increasing the cytosolic peptide pool, which is essential for antigen presentation. In contrast, Concanamycin A alters intracellular pH gradients, a condition that can enhance TAP2-mediated peptide transport.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc(II) Chloride can enhance the functional activity of TAP2 by stabilizing the TAP1/TAP2 complex, increasing its affinity for peptide substrates and promoting the antigen presentation process. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Sodium Fluoride can enhance TAP2 activity by inhibiting phosphatases that would otherwise dephosphorylate proteins involved in the antigen presentation pathway, maintaining a phosphorylation state that favors TAP2 function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts Golgi apparatus function, which can indirectly lead to an upregulation of TAP2 activity due to an increased need for peptides in the endoplasmic reticulum for MHC class I molecule loading. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A, by inhibiting the vacuolar type H+-ATPase, can alter the endosomal/lysosomal pH, potentially resulting in enhanced TAP2 activity due to a favorable peptide transport environment. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E-64 inhibits cysteine proteases, potentially leading to a cytosolic accumulation of peptides available for TAP2 transport, enhancing antigen processing. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 inhibits the proteasome, which can result in an increased pool of peptides for TAP2 transport, indirectly enhancing its antigen processing activity. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin, similar to MG132, inhibits the proteasome, which can indirectly enhance TAP2 activity by increasing the availability of peptide substrates. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a proteasome inhibitor that indirectly enhances TAP2 activity by increasing the availability of peptides for MHC class I loading. | ||||||
Glyoxal, 40 % Solution | 107-22-2 | sc-285868 sc-285868A | 25 ml 50 ml | $89.00 $119.00 | 1 | |
Glyoxal can modify peptides, potentially increasing their affinity for TAP2 and enhancing the efficiency of antigen processing and presentation. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
Dimethyl Sulfoxide (DMSO) can increase membrane permeability, potentially enhancing the access of cytosolic peptides to the TAP2 complex and increasing its functional activity. | ||||||