TAGAP1 Inhibitors
TAGAP1 inhibitors are a class of chemical compounds that target and inhibit the activity of the TAGAP1 (T-cell activation GTPase-activating protein 1) protein, which is involved in the regulation of intracellular signaling pathways. TAGAP1 belongs to the GTPase-activating protein family, which modulates the activity of small GTPases, a group of proteins known for their role in controlling various cellular processes such as cell division, differentiation, and cytoskeletal dynamics. TAGAP1 specifically functions by regulating GTPases involved in immune cell signaling and cytoskeleton rearrangement, making it an important player in cell motility and cellular communication. By inhibiting TAGAP1, researchers can explore the detailed mechanisms by which GTPase activation is controlled and how it impacts cell function.
Inhibitors of TAGAP1 work by blocking the interaction between TAGAP1 and its target GTPases, preventing the normal hydrolysis of GTP to GDP, which is a key step in regulating the activity of GTPases. This inhibition can lead to disruptions in downstream signaling pathways, including those involved in cytoskeletal organization, cell migration, and immune responses. Researchers use TAGAP1 inhibitors to study how the loss of TAGAP1 function affects cellular signaling and the broader impacts on cellular organization and movement. Additionally, inhibiting TAGAP1 provides insights into the regulatory networks that control cell activation, helping to identify how GTPase-activating proteins like TAGAP1 influence cellular homeostasis and the coordination of cellular responses to external stimuli. Through these studies, the use of TAGAP1 inhibitors contributes to a deeper understanding of the role of GTPase regulators in cellular communication and cytoskeletal dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin may inhibit T cell activation GTPase activating protein 1 expression by inhibiting mTOR signaling pathway, which is crucial for the expression of proteins involved in T cell activation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin may inhibit T cell activation GTPase activating protein 1 expression by inhibiting PI3K signaling pathway, which regulates various cellular processes including protein expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD-98059 may inhibit T cell activation GTPase activating protein 1 expression by inhibiting MAPK/ERK signaling pathway, which plays a role in regulating gene expression including protein expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 may inhibit T cell activation GTPase activating protein 1 expression by inhibiting p38 MAPK signaling pathway, which regulates gene expression including the expression of proteins. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 may inhibit T cell activation GTPase activating protein 1 expression by inhibiting MEK/ERK signaling pathway, which is involved in regulating gene expression including protein expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 may inhibit T cell activation GTPase activating protein 1 expression by inhibiting PI3K signaling pathway, which is crucial for the expression of proteins involved in T cell activation. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG-490 may inhibit T cell activation GTPase activating protein 1 expression by inhibiting JAK/STAT signaling pathway, which regulates gene expression including protein expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 may inhibit T cell activation GTPase activating protein 1 expression by inhibiting JNK signaling pathway, which regulates gene expression including the expression of proteins. | ||||||
RKI-1447 | 1342278-01-6 | sc-472590 | 1 mg | $330.00 | ||
GSK'872 may inhibit T cell activation GTPase activating protein 1 expression by inhibiting TBK1/IKKε signaling pathway, which is involved in regulating gene expression including protein expression. | ||||||
5-Iodotubercidin | 24386-93-4 | sc-3531 sc-3531A | 1 mg 5 mg | $150.00 $455.00 | 20 | |
5-Iodotubercidin may inhibit T cell activation GTPase activating protein 1 expression by inhibiting adenosine kinase, leading to decreased adenosine levels, which can modulate gene expression. | ||||||