TAAR3 Inhibitors
TAAR3 inhibitors are a class of chemical compounds that selectively inhibit the trace amine-associated receptor 3 (TAAR3), a member of the TAAR family, which falls under the broader category of G-protein coupled receptors (GPCRs). These receptors are activated by trace amines, a group of endogenous compounds structurally related to well-known neurotransmitters such as dopamine, serotonin, and norepinephrine. TAAR3, in particular, responds to specific trace amines, initiating intracellular signaling processes upon activation. Inhibitors of TAAR3 work by binding to the receptor and preventing its interaction with natural ligands, thereby blocking the receptor's ability to trigger downstream signaling cascades. This inhibition can alter key signaling pathways, including the regulation of cyclic AMP (cAMP) levels or other intracellular messengers that contribute to cellular communication.
The chemical structure of TAAR3 inhibitors varies, with different classes of compounds interacting with the receptor through various mechanisms. Some TAAR3 inhibitors act as competitive antagonists, directly occupying the ligand-binding domain of the receptor and preventing trace amines from activating it. Others may function as allosteric modulators, binding to alternative sites on the receptor that cause a conformational change, reducing the receptor's ability to respond to trace amines. These inhibitors influence the signaling pathways typically mediated by TAAR3, which are integral to many biological processes involving G-protein activation and downstream effects, such as calcium flux or changes in other intracellular signaling molecules. By blocking TAAR3 activity, these inhibitors provide valuable insights into the role of this receptor subtype in physiological systems and the broader dynamics of trace amine signaling. This contributes to the expanding understanding of the complex interactions between trace amines and their receptors within the nervous system and other tissues.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may inhibit the expression of trace amine-associated receptor 3 by interfering with transcription factors and downregulating gene expression. Its anti-inflammatory properties might impact signaling pathways involved in the expression of this protein. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol's ability to modulate transcription factors and inhibit gene expression could lead to the downregulation of trace amine-associated receptor 3. Its antioxidant properties may also contribute to reducing the expression of this protein. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can potentially inhibit the expression of trace amine-associated receptor 3 by modulating various signaling pathways involved in gene expression regulation. Its antioxidant properties may also contribute to reducing the expression of this protein. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin's modulation of signaling pathways and inhibition of transcription factors might result in the downregulation of trace amine-associated receptor 3 expression. Additionally, its antioxidant properties could play a role in reducing the expression of this protein. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine's interference with transcription factors and modulation of gene expression may lead to the inhibition of trace amine-associated receptor 3 expression. Its anti-inflammatory effects might also impact relevant signaling pathways involved in the expression of this protein. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein's ability to modulate transcription factors and signaling pathways involved in gene expression could result in the downregulation of trace amine-associated receptor 3. Additionally, its anti-inflammatory properties may influence the expression of this protein. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin's modulation of gene expression through various signaling pathways may inhibit the expression of trace amine-associated receptor 3. Its anti-inflammatory effects might also contribute to reducing the expression of this protein by impacting relevant pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane may inhibit the expression of trace amine-associated receptor 3 by modulating gene expression through epigenetic mechanisms and inhibiting transcription factors. Its anti-inflammatory properties could also impact signaling pathways involved in the expression of this protein. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $103.00 $210.00 $6132.00 | 2 | |
Emodin's interference with transcription factors and modulation of signaling pathways may lead to the inhibition of trace amine-associated receptor 3 expression. Additionally, its anti-inflammatory effects could influence relevant pathways involved in the expression of this protein. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin's modulation of signaling pathways and inhibition of transcription factors might result in the downregulation of trace amine-associated receptor 3 expression. Additionally, its antioxidant properties could contribute to reducing the expression of this protein. | ||||||