T2R60 Activators
T2R60, a member of the bitter taste receptor family, responds to a wide range of bitter compounds. Each of these compounds, in their interaction with T2R60, triggers the G-protein-coupled receptor signaling pathway, leading to an increase in intracellular calcium levels. Compounds such as quinine, denatonium, and chloroquine are renowned for their bitter taste and their ability to activate T2R60. Alkaloids like yohimbine and theobromine also stimulate the receptor, increasing its functional activity. This activation is not limited to naturally occurring compounds; synthesized molecules like denatonium also exhibit this ability.
Other chemicals, including berberine, caffeine, colchicine, gentamicin, salicin, amygdalin, and parthenolide, have demonstrated the potential to interact with T2R60, initiating the G-protein signaling pathway and enhancing intracellular calcium levels. The bitter taste associated with these compounds arises from their activation of T2R60, among other bitter taste receptors. It is noteworthy that, despite their structural diversity, all these compounds activate T2R60 in a similar manner, underscoring the receptor's adaptability and its significant role in detecting a wide range of bitter compounds.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
This alkaloid is a potent activator of various bitter taste receptors including T2R60. Its binding to the receptor stimulates the G-protein coupled receptor signaling pathway leading to an increase in intracellular calcium levels and hence enhancing the function of T2R60. | ||||||
Denatonium benzoate | 3734-33-6 | sc-234525 sc-234525A sc-234525B sc-234525C sc-234525D | 1 g 5 g 25 g 100 g 250 g | $32.00 $47.00 $141.00 $473.00 $921.00 | ||
Known as the most bitter compound, denatonium activates T2R60. It triggers the G-protein signaling pathway causing an increase in intracellular calcium levels, thereby increasing T2R60 activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is a bitter compound that can activate T2R60. It increases intracellular calcium via G-protein signaling pathway, enhancing T2R60 function. | ||||||
Yohimbine hydrochloride | 65-19-0 | sc-204412 sc-204412A sc-204412B | 1 g 5 g 25 g | $51.00 $171.00 $530.00 | 2 | |
Yohimbine is a bitter alkaloid that activates T2R60. It initiates G-protein signaling which causes an increase in intracellular calcium, leading to increased T2R60 function. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine, a bitter compound, can stimulate T2R60. It enhances T2R60 function by triggering G-protein signaling and the subsequent increase in intracellular calcium levels. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
As a bitter compound, caffeine can activate T2R60. It increases intracellular calcium via G-protein signaling, enhancing T2R60 function. | ||||||
Theobromine | 83-67-0 | sc-203296 sc-203296A | 25 g 100 g | $42.00 $89.00 | ||
A bitter alkaloid, theobromine can activate T2R60. It enhances T2R60 function by triggering the G-protein signaling pathway and increasing intracellular calcium. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine, a bitter compound, can stimulate T2R60. It triggers the G-protein signaling pathway, causing an increase in intracellular calcium levels, thereby increasing T2R60 activity. | ||||||
Gentamicin Sulfate, 500X Solution | 1405-41-0 | sc-29066A sc-29066 | 10 ml 20 ml | $48.00 $85.00 | 12 | |
This bitter compound activates T2R60. It triggers the G-protein signaling pathway resulting in an increase in intracellular calcium levels, which enhances T2R60 function. | ||||||
D-(−)-Salicin | 138-52-3 | sc-218004 | 5 g | $59.00 | ||
As a bitter compound, salicin can activate T2R60. It increases intracellular calcium via G-protein signaling, enhancing T2R60 function. | ||||||