Tβ-15a Inhibitors
Tβ-15a, also known as Transforming Growth Factor β-15a, is a protein belonging to the Transforming Growth Factor β (TGF-β) superfamily, with diverse roles in cellular processes such as cell growth, differentiation, and immune regulation. Its activity is tightly regulated to maintain tissue homeostasis, and dysregulation of Tβ-15a signaling has been implicated in various pathological conditions, including cancer, fibrosis, and immune disorders. Inhibition of Tβ-15a represents a strategy for modulating its aberrant activity in disease states.
The inhibition of Tβ-15a involves targeting different stages of its signaling pathway to impede its function. One approach to inhibition is to block its interaction with cell surface receptors, preventing the initiation of downstream signaling cascades. Additionally, strategies aimed at disrupting intracellular signaling pathways downstream of Tβ-15a receptors can effectively inhibit its biological effects. This can be achieved through the inhibition of Smad-dependent and Smad-independent pathways or through crosstalk with other signaling networks such as MAPK and PI3K/AKT pathways. Overall, understanding the mechanisms underlying Tβ-15a inhibition offers insights into interventions for diseases associated with dysregulated TGF-β signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Inhibits actin polymerization, which can alter cellular processes that TMSB15A might be involved in. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Binds to actin monomers and prevents their polymerization, potentially affecting TMSB15A's role in actin dynamics. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Stabilizes actin filaments and can indirectly affect TMSB15A by altering the equilibrium of actin polymerization. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Severs actin filaments and prevents polymerization, which may influence TMSB15A-related pathways. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
Stabilizes actin filaments, which can indirectly influence TMSB15A interaction with actin. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Inhibits formin-mediated actin assembly, which can impact cellular processes where TMSB15A is implicated. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Inhibits myosin II, and can indirectly affect cellular mechanisms that TMSB15A might affect. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase, can impact actin-myosin interaction and processes involving TMSB15A. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Inhibits ROCK kinase, which can alter actin dynamics and potentially the function of TMSB15A. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Inhibits the N-WASP-Arp2/3 complex, which can affect actin-related processes involving TMSB15A. | ||||||