Syne-4 Activators
Syne-4 activators primarily work by influencing the phosphorylation status of proteins involved in actin cytoskeleton organization, a process in which Syne-4 plays a significant role. Several of these activators, including Forskolin and IBMX, increase cAMP levels in cells, which subsequently activate protein kinase A (PKA). Activated PKA can phosphorylate proteins involved in actin cytoskeleton organization, indirectly enhancing the activity of Syne-4. Anisomycin, another activator, triggers the stress-activated protein kinase (SAPK)/JNK pathway, which is involved in actin cytoskeleton organization, indirectly enhancing Syne-4's function. Dibutyryl-cAMP, a membrane-permeable cAMP analogue, achieves a similar effect by activating PKA.
Certain Syne-4 activators work by inhibiting protein phosphatases and maintaining the phosphorylation status of proteins involved in the actin cytoskeleton organization. Okadaic acid and Calyculin A inhibit protein phosphatases 1 and 2A, thereby indirectly maintaining the active state of Syne-4 and enhancing its role in the process. Cyclosporin A, an inhibitor of calcineurin, a phosphatase, accomplishes a similar function. Other activators, like H-89, Staurosporine, Rapamycin, and Lithium Chloride, influence different kinases that can affect the phosphorylation of proteins involved in actin cytoskeleton organization, indirectly enhancing the role of Syne-4 in this process.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases cAMP levels in cells. cAMP activates protein kinase A (PKA), which is known to phosphorylate a variety of proteins. Since Syne-4 is involved in the organization of actin cytoskeleton, PKA can phosphorylate proteins involved in this process, indirectly enhancing the activity of Syne-4. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterases, thus preventing the breakdown of cAMP in cells. Elevated cAMP levels activate PKA, which can phosphorylate proteins involved in actin cytoskeleton organization, a process in which Syne-4 plays a significant role, thereby indirectly enhancing Syne-4 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate proteins involved in the organization of actin cytoskeleton. By activating PKC, PMA indirectly enhances the functional activity of Syne-4 in this process. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid inhibits protein phosphatases 1 and 2A. By preventing the dephosphorylation of proteins involved in actin cytoskeleton organization, it indirectly maintains the active state of Syne-4, thereby enhancing its role in this process. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, preventing the dephosphorylation of proteins involved in actin cytoskeleton organization. This indirectly maintains the active state of Syne-4, enhancing its role in this process. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a potent activator of the stress-activated protein kinase (SAPK)/JNK pathway. This pathway is involved in actin cytoskeleton organization, a process in which Syne-4 plays a significant role. Thus, Anisomycin can indirectly enhance the functional activity of Syne-4. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a membrane-permeable cAMP analogue that activates PKA. PKA can phosphorylate proteins that are a part of the actin cytoskeleton organization process, indirectly enhancing Syne-4 activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC. By inhibiting PKC, it can affect proteins involved in actin organization, indirectly enhancing Syne-4's role in this process. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an inhibitor of calcineurin, a phosphatase that can dephosphorylate proteins involved in actin cytoskeleton organization. By inhibiting calcineurin, it indirectly maintains the active state of Syne-4, enhancing its role. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a kinase that can phosphorylate proteins involved in actin cytoskeleton organization. By inhibiting mTOR, it indirectly maintains the active state of Syne-4, enhancing its role. | ||||||