Syndecan-4 Activators
Syndecan-4 Activators are a chemically diverse group of compounds that target various signaling pathways or cellular processes to activate the Syndecan-4 protein. These compounds cover a broad spectrum, including lipids, ions, organic molecules, and more. Phorbol 12-myristate 13-acetate (PMA) and UTP are notable examples that activate protein kinase C and P2Y receptors, respectively. Their activation leads to subsequent intracellular signaling cascades that result in Syndecan-4 activation. Similarly, Calcium Ionophore A23187 and Epinephrine modify calcium and adrenergic pathways, leading to the activation of Syndecan-4.
Other compounds like Eicosapentaenoic Acid (EPA) and Arachidonic Acid focus on lipid-based mechanisms to modulate Syndecan-4 function. They influence the lipid composition of cellular membranes and associated signaling pathways, thereby affecting Syndecan-4's role in cell adhesion and other cellular processes. Spermine on the other hand, acts more indirectly but effectively. Spermine interacts with cellular membranes to enhance Syndecan-4's role in cell adhesion. The activation mechanisms are varied but converge on the common outcome of Syndecan-4 activation, making this a versatile and potent class of activators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C, which in turn activates Syndecan-4 by phosphorylation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Increases intracellular calcium levels, thereby activating Syndecan-4 through calcium-dependent pathways. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
Binds to its receptor and activates Syndecan-4 through downstream signaling. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Binds to adrenergic receptors, initiating cascades that lead to Syndecan-4 activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase and elevates cAMP levels, thereby activating Syndecan-4 through PKA. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Elevates Syndecan-4 by interacting with cellular membranes, thereby facilitating its role in cell adhesion. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
Activates Syndecan-4 by modulating cellular lipid rafts and associated signaling. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Modulates Syndecan-4 function by altering the lipid composition of cellular membranes. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Induces Syndecan-4 clustering and activation, which facilitates its role in focal adhesion and cell migration. | ||||||