Syndecan-4 Inhibitors
Syndecan-4 inhibitors are chemical agents designed to modulate the activity of the syndecan-4 protein, a cell surface heparan sulfate proteoglycan. Syndecan-4 belongs to the syndecan family, which has four members (syndecan-1 through syndecan-4) identified in mammalian cells. These proteoglycans are mainly involved in cellular communication, adhesion, and migration. Syndecans have a core protein to which heparan sulfate glycosaminoglycan chains are attached, and this core protein is embedded in the cell membrane through a single transmembrane domain.
The syndecans interact with various extracellular matrix components and cell surface receptors, including integrins and growth factor receptors, to modulate a variety of cellular functions. Syndecan-4, in particular, is known for its role in cell-matrix interactions, cell morphology, and intracellular signaling cascades.Syndecan-4 inhibitors work by interfering with the function of the syndecan-4 protein in various ways. Some inhibitors bind directly to the core protein, while others may interfere with the heparan sulfate chains.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PF-2545920 | 1292799-56-4 | sc-364355 sc-364355A | 5 mg 10 mg | $405.00 $555.00 | ||
PF-2545920 inhibits syndecan-4 through an unknown mechanism, potentially disrupting its binding to extracellular matrix components. | ||||||
TAK 285 | 871026-44-7 | sc-364627 sc-364627A | 5 mg 10 mg | $405.00 $700.00 | ||
TAK-285 inhibits syndecan-4 by downregulating its expression, leading to decreased cell proliferation and invasion. | ||||||
Verteporfin | 129497-78-5 | sc-475698 sc-475698A | 10 mg 100 mg | $354.00 $2764.00 | 5 | |
Verteporfin inhibits syndecan-4 by disrupting its association with YAP, inhibiting cell growth and invasion in cancer cells. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin inhibits syndecan-4 by binding to its heparan sulfate chains, interfering with cell adhesion and angiogenesis. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $312.00 | 1 | |
BMS-345541 inhibits syndecan-4 by blocking the NF-κB pathway, reducing inflammation and cell migration. | ||||||
PF-429242 | 947303-87-9 | sc-507498 | 5 mg | $176.00 | ||
PF-429242 inhibits syndecan-4 by interfering with its binding to α5β1 integrin, inhibiting cell adhesion and migration. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits syndecan-4 by downregulating its expression and reducing cell proliferation and migration in cancer cells. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $64.00 $131.00 $204.00 | 6 | |
GANT-61 inhibits syndecan-4 indirectly by targeting the Hedgehog signaling pathway, reducing cell growth and invasion. | ||||||