SYAP1 Activators
Activators of SYAP1 exert their influence through a variety of signaling cascades, each converging on the modulation of this synapse-associated protein's activity. Certain activators target the adenylyl cyclase pathway, leading to an upsurge in intracellular cyclic AMP (cAMP) levels. This elevation in cAMP activates protein kinase A (PKA), a kinase with broad substrate specificity, which then phosphorylates target proteins including SYAP1, thus enhancing their activity. In parallel, some activators function by inhibiting cAMP or cyclic GMP (cGMP) degrading phosphodiesterases, resulting in amplified levels of these cyclic nucleotides within the cell and subsequent activation of their respective dependent protein kinases. These kinases, upon activation, can then phosphorylate SYAP1 or other associated proteins that modulate SYAP1's functional state.
In addition to cAMP and cGMP pathways, other activators influence intracellular calcium levels, which is a crucial secondary messenger in a multitude of signaling pathways. By either directly increasing calcium levels or acting on calcium-dependent enzymes, such as calmodulin-dependent kinases, these activators can alter the phosphorylation status of SYAP1, thereby modulating its activity. Some activators may also impact NAD+ metabolism and sirtuin activity, which are associated with deacetylation processes that can affect SYAP1 function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator which increases intracellular cAMP levels, indirectly enhancing SYAP1 activity through PKA-mediated phosphorylation events. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Non-specific inhibitor of phosphodiesterases, leading to increased cAMP levels which may enhance SYAP1 activity via PKA-dependent signaling cascades. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activator of protein kinase C (PKC) which could lead to SYAP1 activation through PKC-dependent phosphorylation pathways. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Activates insulin receptor signaling pathways that could lead to the activation of downstream effectors like SYAP1. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Calcium ionophore that raises intracellular calcium levels, potentially activating SYAP1 through calcium/calmodulin-dependent protein kinase pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore it could activate SYAP1 by elevating intracellular calcium and engaging calcium-dependent signaling mechanisms. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Beta-adrenergic agonist that increases cAMP levels, potentially leading to SYAP1 activation through cAMP-dependent pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Inhibitor of phosphodiesterase 4, increases cAMP levels which may activate SYAP1 through cAMP-dependent protein kinase A (PKA). | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Phosphodiesterase inhibitor, particularly of PDE5, leading to increased cGMP levels and potentially enhancing SYAP1 activity through cGMP-dependent pathways. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
NAD+ precursor which could enhance SYAP1 activity by influencing sirtuin-dependent deacetylation pathways linked to synaptic function. | ||||||