SVEP1 Inhibitors
SVEP1 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of SVEP1 (Sushi, Von Willebrand factor type A, EGF, and Pentraxin domain-containing 1), a multi-domain extracellular matrix protein. SVEP1 plays a critical role in various cellular processes, including cell adhesion, tissue organization, and extracellular matrix formation. It is predominantly expressed in tissues such as the skin, blood vessels, and the developing cardiovascular system, where it contributes to the structural integrity and signaling functions required for proper tissue development and maintenance. Inhibitors of SVEP1 work by disrupting its ability to interact with other cellular and matrix components, such as integrins or other adhesion molecules, thereby altering cellular adhesion and communication processes within the extracellular matrix.
The mechanisms through which SVEP1 inhibitors operate can vary, depending on the specific domains of the protein they target. Some inhibitors may bind directly to the Sushi or EGF-like domains of SVEP1, blocking its interaction with cellular receptors or extracellular matrix components. Others might alter the conformation of SVEP1, reducing its ability to organize or support the extracellular matrix's structural framework. By inhibiting SVEP1, these compounds disrupt cellular communication and adhesion processes that are crucial for tissue architecture and integrity. Studying SVEP1 inhibitors provides valuable insights into the molecular mechanisms that govern extracellular matrix dynamics and cell-to-matrix interactions. This research deepens the understanding of how proteins like SVEP1 regulate the mechanical and signaling properties of tissues, contributing to the maintenance of tissue homeostasis and organization in complex biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D inhibits RNA polymerase activity, thereby blocking transcription of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 gene. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein synthesis, leading to decreased expression of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 protein. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR signaling, which may affect pathways regulating the expression of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 protein. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin inhibits PI3K, a kinase involved in cellular signaling pathways that regulate the expression of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 protein. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits protein glycosylation, potentially affecting protein folding and secretion, thus influencing the expression of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 protein. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases, potentially altering chromatin structure and influencing the expression of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 protein. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that can modulate signaling pathways, potentially influencing the expression of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 protein. | ||||||
SB 218078 | 135897-06-2 | sc-203692 | 1 mg | $133.00 | 1 | |
SB-218078 inhibits GSK-3β, a kinase involved in cellular signaling, which may impact pathways regulating the expression of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 protein. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 inhibits vacuolar ATPase, potentially affecting cellular processes that regulate the expression of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 protein. | ||||||
GSK1904529A | 1089283-49-7 | sc-507398 | 10 mg | $321.00 | ||
GSK1904529A inhibits PI3K and mTOR, key kinases in cellular signaling pathways that regulate the expression of the sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 protein. | ||||||