SVCT1 Inhibitors
SVCT1 inhibitors belong to a specific chemical class characterized by their ability to interact with and modulate the activity of the Sodium-dependent Vitamin C Transporter 1 (SVCT1). This transporter is a key membrane protein responsible for the uptake of vitamin C (ascorbic acid) from the extracellular environment into the cells, thereby playing a crucial role in maintaining cellular vitamin C levels. The inhibitors in this class are diverse and can include both natural and synthetic compounds. Some natural SVCT1 inhibitors are found in plant sources, such as flavonoids found in fruits and vegetables like green tea-derived epigallocatechin gallate (EGCG), quercetin, and resveratrol from grapes.
Synthetic SVCT1 inhibitors, on the other hand, may include chemical compounds like sulfinpyrazone, indomethacin, and flurbiprofen, which are originally designed for different purposes but have demonstrated inhibitory effects on the SVCT1 transporter. These inhibitors have been the subject of scientific research to better understand cellular vitamin C regulation and the transport mechanisms involved. However, further investigation is needed to fully elucidate their mechanisms of action and their impact on vitamin C homeostasis in cells.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Sulfinpyrazone | 57-96-5 | sc-202822 sc-202822A | 1 g 5 g | $42.00 $94.00 | 2 | |
Originally developed as an anti-gout agent in research, sulfinpyrazone was found to inhibit SVCT1 and limit the absorption of vitamin C. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
This non-steroidal anti-inflammatory drug (NSAID) has been identified as an SVCT1 inhibitor in certain studies. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Another NSAID, aspirin, has shown inhibitory effects on SVCT1 activity, potentially leading to reduced vitamin C uptake. | ||||||
Benzoic acid | 65-85-0 | sc-203317 sc-203317A sc-203317B | 25 g 100 g 500 g | $20.00 $51.00 $61.00 | ||
Benzoic acid and its derivatives have been investigated as SVCT1 inhibitors due to their structural similarities to ascorbic acid. | ||||||
Protocatechuic acid | 99-50-3 | sc-205818 sc-205818A | 25 g 50 g | $132.00 $264.00 | 9 | |
This compound has been studied for its ability to inhibit SVCT1 and affect vitamin C transport. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A type of flavonoid found in green tea, EGCG has been proposed to inhibit SVCT1-mediated vitamin C uptake. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, another flavonoid, has been shown to modulate SVCT1 activity and potentially influence vitamin C absorption. | ||||||
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $64.00 $255.00 | 13 | |
This natural phenolic compound found in apples and other fruits has been investigated for its ability to inhibit SVCT1. | ||||||
Phloridzin dihydrate | 7061-54-3 | sc-215708 sc-215708A | 250 mg 1 g | $49.00 $119.00 | ||
Another compound found in apples, phloridzin, has been suggested as an SVCT1 inhibitor. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in grapes and red wine, has been studied for its potential to inhibit SVCT1 activity. | ||||||