SV40 T Ag Inhibitors
Simian Virus 40 (SV40) is a polyomavirus originally discovered in monkey kidney cells, and its T antigen (T Ag) has been extensively studied due to its ability to induce cellular transformation and its involvement in viral replication. The SV40 T Ag is a multifunctional protein that plays a central role in the viral life cycle and has the capability to perturb the normal regulatory mechanisms of host cells. One of the primary mechanisms by which the T Ag exerts its influence is through its interaction with cellular proteins, most notably the tumor suppressors p53 and members of the retinoblastoma (Rb) protein family. By binding to these proteins, T Ag disrupts their normal tumor-suppressive functions, leading to uncontrolled cell proliferation, a hallmark of transformation.
SV40 T Ag inhibitors are chemical compounds specifically designed to obstruct the activities of the SV40 T antigen. These inhibitors can work through various mechanisms, such as preventing the binding of T Ag to its cellular targets like p53 or Rb, inhibiting its ATPase activity, or blocking its helicase function, which is crucial for viral DNA replication.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, can inhibit the activity of SV40 T Ag, affecting the virus's ability to transform cells. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
This flavonoid can inhibit the function of SV40 T Ag, potentially blocking its interaction with cellular proteins. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid can disrupt SV40 T Ag function, affecting the viral life cycle and transformation ability. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
This flavonoid can inhibit SV40 T Ag activity, blocking its transformation potential. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine can affect SV40 replication, potentially through interactions with T Ag. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can suppress the function of SV40 T Ag, affecting viral replication and transformation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can inhibit SV40 T Ag's ability to transform cells, affecting viral oncogenesis. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
This flavonoid can block SV40 T Ag function, impacting the virus's life cycle. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Fisetin can inhibit the activity of SV40 T Ag, affecting viral replication and transformation. | ||||||
Galangin | 548-83-4 | sc-235240 | 25 mg | $133.00 | 5 | |
This flavonoid can suppress SV40 T Ag function, potentially impacting viral oncogenesis. | ||||||