SURF-1 Inhibitors
SURF-1 inhibitors target and inhibit the function of the SURF-1 protein. SURF-1, an acronym for "Surfeit locus protein 1," is a vital component of the mitochondrial respiratory chain complex IV, also known as cytochrome c oxidase. Complex IV is a key enzyme complex in the electron transport chain, responsible for the final step of aerobic respiration, where electrons are transferred from cytochrome c to molecular oxygen, leading to the production of water. The inhibition of SURF-1 disrupts the assembly and stability of complex IV, subsequently impairing the overall efficiency of oxidative phosphorylation, a fundamental process for the generation of adenosine triphosphate (ATP), the primary energy currency of cells.
The inhibition of SURF-1 by these compounds can have wide-ranging implications in the study of cellular bioenergetics and mitochondrial function. It offers researchers a valuable tool to investigate the role of complex IV in energy production and mitochondrial physiology. By interfering with SURF-1 activity, these inhibitors can lead to mitochondrial dysfunction, which can trigger various cellular responses, including changes in gene expression, cellular stress pathways, and potentially, apoptosis.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin intercalates DNA and may downregulate SURF-1 expression by inhibiting transcription factors necessary for its expression. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Chloramphenicol inhibits bacterial protein synthesis and might indirectly affect mitochondrial protein synthesis, potentially reducing SURF-1 expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and may hinder transcription, possibly reducing SURF-1 mRNA synthesis and subsequent protein levels. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin binds to bacterial RNA polymerase and could affect mitochondrial RNA polymerase, hypothetically decreasing SURF-1 expression. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis and could reduce SURF-1 levels by preventing its translation. | ||||||
5,5-Diphenyl Hydantoin | 57-41-0 | sc-210385 | 5 g | $70.00 | ||
Phenytoin, known to affect neural development, might alter mitochondrial function and indirectly modulate SURF-1 expression levels. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid modulates gene expression and could influence the transcriptional regulation of genes like SURF-1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can change chromatin structure, potentially affecting SURF-1 gene expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin inhibits RNA polymerase II, possibly leading to decreased mRNA transcription of SURF-1. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $48.00 $150.00 $588.00 $2086.00 | 12 | |
Ethidium Bromide intercalates into DNA, which could reduce the transcriptional activity of genes such as SURF-1. | ||||||