Supervillin Inhibitors
Supervillin inhibitors belong to a class of chemical compounds that have garnered significant attention in the field of molecular biology and cell biology. These inhibitors specifically target supervillin, a multifunctional protein found in various cell types, particularly in muscle cells and the nervous system. Supervillin itself plays a crucial role in regulating actin cytoskeleton dynamics, cell adhesion, and cell motility. The chemical class of supervillin inhibitors is designed to modulate the function of supervillin, which in turn can have far-reaching effects on various cellular processes.
Supervillin inhibitors are engineered to disrupt the interactions and binding affinity between supervillin and its cellular binding partners. This disruption can result in alterations to the organization and stability of the actin cytoskeleton, which is essential for maintaining cell shape, cell motility, and intracellular transport. By inhibiting supervillin, these compounds can perturb the intricate balance of cellular activities, leading to changes in cell morphology and behavior. Researchers have been exploring the use of supervillin inhibitors as valuable tools in cell biology experiments to elucidate the precise mechanisms underlying cell motility and cytoskeletal dynamics.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Binds to the barbed ends of actin filaments, preventing polymerization and thus potentially affecting supervillin's interaction with the actin cytoskeleton. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Sequesters G-actin monomers, disrupting actin polymerization and potentially altering supervillin-mediated actin dynamics. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibits myosin light chain kinase, which could alter cell motility and tension, processes where supervillin may play a role. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits ROCK (Rho-associated protein kinase), which is involved in actin filament stabilization; this may indirectly affect supervillin's role in actin structures. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits myosin II ATPase activity, potentially altering the contractile processes where supervillin might be involved. | ||||||
ATM/ATR Kinase Inhibitor Inhibitor | 905973-89-9 | sc-202964 | 5 mg | $106.00 | 8 | |
Inhibits formin-mediated actin assembly, potentially altering actin dynamics and supervillin's association with actin filaments. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Inhibits Arp2/3 complex, which is involved in actin nucleation, potentially affecting supervillin's role in organizing the actin cytoskeleton. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments and can induce actin polymerization, which may affect supervillin's actin-modulating activities. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Inhibits the N-WASP-activated ARP2/3 complex, potentially affecting actin dynamics and supervillin's interactions with the cytoskeleton. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Inhibits Protein Kinase C, which is involved in actin cytoskeleton organization; this could indirectly impact supervillin's function. | ||||||