Supervillin Antibody (B8C1): sc-53556
- Supervillin Antibody (B8C1) is a mouse monoclonal IgG2b κ Supervillin antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-340 of Supervillin of human origin
- Supervillin Antibody (B8C1) is recommended for detection of Supervillin of mouse, rat and human origin by WB, IP and IF
- Anti-Supervillin Antibody (B8C1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Supervillin Antibody (B8C1) for WB applications. This reagent is now offered in a bundle with Supervillin Antibody (B8C1) (see ordering information below).
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Supervillin Antibody (B8C1) is a mouse monoclonal IgG2b kappa light chain antibody that detects Supervillin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Supervillin antibody (B8C1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Supervillin plays a crucial role in actin filament remodeling and is essential for various cellular processes such as cell motility, apoptosis regulation, and phagocytosis. Supervillin is primarily located at the plasma membrane and is tightly associated with actin filaments, which is vital for maintaining cell shape and facilitating cellular movement. Supervillin′s presence at the plasma membrane underscores its importance in processes like cell adhesion and migration, which are critical for tissue development and repair. Additionally, Supervillin is ubiquitously expressed across different tissues, with a non-muscle-specific isoform capable of activating androgen receptor activity, while the muscle-specific isoform, known as Archvillin, contributes to myogenic membrane structures and differentiation. This multifaceted role of Supervillin highlights its significance in both normal cellular functions and potential implications in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Supervillin Antibody (B8C1) References:
- Supervillin associates with androgen receptor and modulates its transcriptional activity. | Ting, HJ., et al. 2002. Proc Natl Acad Sci U S A. 99: 661-6. PMID: 11792840
- Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton. | Oh, SW., et al. 2003. J Cell Sci. 116: 2261-75. PMID: 12711699
- F-actin and myosin II binding domains in supervillin. | Chen, Y., et al. 2003. J Biol Chem. 278: 46094-106. PMID: 12917436
- Actin monomer enhances supervillin-modulated androgen receptor transactivation. | Ting, HJ., et al. 2004. Biochem Biophys Res Commun. 319: 393-6. PMID: 15178419
- Smooth muscle archvillin: a novel regulator of signaling and contractility in vascular smooth muscle. | Gangopadhyay, SS., et al. 2004. J Cell Sci. 117: 5043-57. PMID: 15383618
- The flightless I protein and the gelsolin family in nuclear hormone receptor-mediated signalling. | Archer, SK., et al. 2004. Biochem Soc Trans. 32: 940-2. PMID: 15506930
- Gelsolin superfamily proteins: key regulators of cellular functions. | Silacci, P., et al. 2004. Cell Mol Life Sci. 61: 2614-23. PMID: 15526166
- Supervillin (p205): A novel membrane-associated, F-actin-binding protein in the villin/gelsolin superfamily. | Pestonjamasp, KN., et al. 1997. J Cell Biol. 139: 1255-69. PMID: 9382871
- Cloning, characterization, and chromosomal localization of human superillin (SVIL). | Pope, RK., et al. 1998. Genomics. 52: 342-51. PMID: 9867483
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Supervillin Antibody (B8C1) | sc-53556 | 200 µg/ml | $316.00 | |||
Supervillin Antibody (B8C1): m-IgG Fc BP-HRP Bundle | sc-525605 | 200 µg Ab; 10 µg BP | $354.00 | |||
Supervillin Antibody (B8C1) AC | sc-53556 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Supervillin Antibody (B8C1) HRP | sc-53556 HRP | 200 µg/ml | $316.00 | |||
Supervillin Antibody (B8C1) FITC | sc-53556 FITC | 200 µg/ml | $330.00 | |||
Supervillin Antibody (B8C1) PE | sc-53556 PE | 200 µg/ml | $343.00 | |||
Supervillin Antibody (B8C1) Alexa Fluor® 488 | sc-53556 AF488 | 200 µg/ml | $357.00 | |||
Supervillin Antibody (B8C1) Alexa Fluor® 546 | sc-53556 AF546 | 200 µg/ml | $357.00 | |||
Supervillin Antibody (B8C1) Alexa Fluor® 594 | sc-53556 AF594 | 200 µg/ml | $357.00 | |||
Supervillin Antibody (B8C1) Alexa Fluor® 647 | sc-53556 AF647 | 200 µg/ml | $357.00 | |||
Supervillin Antibody (B8C1) Alexa Fluor® 680 | sc-53556 AF680 | 200 µg/ml | $357.00 | |||
Supervillin Antibody (B8C1) Alexa Fluor® 790 | sc-53556 AF790 | 200 µg/ml | $357.00 |