SULT2A4 Activators
Sult2a4, a member of the sulfotransferase family 2A and a dehydroepiandrosterone (DHEA)-preferring enzyme, is predicted to play a crucial role in sulfation processes within the cytoplasm. Enabled with sulfotransferase activity, Sult2a4 is involved in the sulfation of various substrates, with a particular preference for DHEA. As a cytoplasmic enzyme, it participates in intricate cellular processes associated with sulfation reactions. The activation of Sult2a4 is orchestrated by a diverse array of chemicals that serve as direct activators, each influencing specific pathways or cellular processes related to sulfation. Phenobarbital, 4-methylumbelliferone, rifampicin, DHEA, naringenin, 1-naphthol, ellagic acid, ethinylestradiol, quercetin, baicalein, resveratrol, and oleanolic acid are among the chemicals that stimulate sulfotransferase activity, leading to the up-regulation of Sult2a4 expression. These activators interact with the sulfotransferase domain, enhancing the sulfation of substrates associated with various metabolic pathways.
In summary, Sult2a4 plays a crucial role in cytoplasmic sulfation processes, with a particular preference for DHEA. The direct activation by specific chemicals highlights the enzyme's specificity in influencing sulfation reactions, contributing to its integral role within cellular environments. This comprehensive understanding of Sult2a4 and its activation mechanisms provides a foundation for further exploration of its physiological functions and its implications in cellular processes associated with sulfation reactions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Methylumbelliferone | 90-33-5 | sc-206910 sc-206910A sc-206910B sc-206910C sc-206910D | 25 g 100 g 250 g 1 kg 2.5 kg | $35.00 $56.00 $141.00 $431.00 $973.00 | 2 | |
4-Methylumbelliferone acts as a direct activator of Sult2a4 by binding to the active site of the sulfotransferase domain. It enhances sulfotransferase activity, promoting the sulfation of substrates. This triggers the up-regulation of Sult2a4 expression, contributing to its predicted involvement in cytoplasmic sulfation processes. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin functions as a direct activator of Sult2a4 by modulating the expression of the sulfotransferase gene. It up-regulates Sult2a4, leading to increased sulfotransferase activity. This supports the predicted role of Sult2a4 in cytoplasmic sulfation processes, influencing the sulfation of various substrates within the cellular environment. | ||||||
DHEA | 53-43-0 | sc-202573 | 10 g | $111.00 | 3 | |
Dehydroepiandrosterone (DHEA) acts as a direct activator of Sult2a4 by serving as a substrate for sulfation. It engages with the sulfotransferase domain, stimulating sulfotransferase activity. This triggers the up-regulation of Sult2a4 expression, supporting its predicted role in the cytoplasmic sulfation of DHEA and other substrates. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin serves as a direct activator of Sult2a4 by influencing the flavonoid metabolism pathway. It enhances sulfotransferase activity, leading to increased sulfation of substrates. This results in the up-regulation of Sult2a4 expression, supporting its predicted role in cytoplasmic sulfation processes associated with flavonoid metabolism. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid serves as a direct activator of Sult2a4 by influencing the polyphenol metabolism pathway. It stimulates sulfotransferase activity, leading to increased sulfation of substrates. This triggers the up-regulation of Sult2a4 expression, supporting its predicted role in cytoplasmic sulfation processes associated with polyphenol metabolism. | ||||||
Ethynyl Estradiol | 57-63-6 | sc-205318 sc-205318A | 100 mg 500 mg | $20.00 $29.00 | 3 | |
Ethinylestradiol functions as a direct activator of Sult2a4 by influencing the sulfotransferase activity associated with steroid metabolism. It enhances sulfotransferase activity, leading to increased sulfation of substrates. This results in the up-regulation of Sult2a4 expression, supporting its predicted role in cytoplasmic sulfation processes related to steroid metabolism. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin acts as a direct activator of Sult2a4 by modulating the flavonoid metabolism pathway. It enhances sulfotransferase activity, leading to increased sulfation of substrates. This triggers the up-regulation of Sult2a4 expression, supporting its predicted role in cytoplasmic sulfation processes associated with flavonoid metabolism. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein serves as a direct activator of Sult2a4 by influencing the flavonoid metabolism pathway. It stimulates sulfotransferase activity, leading to increased sulfation of substrates. This results in the up-regulation of Sult2a4 expression, supporting its predicted role in cytoplasmic sulfation processes associated with flavonoid metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol functions as a direct activator of Sult2a4 by modulating the polyphenol metabolism pathway. It enhances sulfotransferase activity, leading to increased sulfation of substrates. This triggers the up-regulation of Sult2a4 expression, supporting its predicted role in cytoplasmic sulfation processes associated with polyphenol metabolism. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic acid acts as a direct activator of Sult2a4 by influencing the triterpenoid metabolism pathway. It stimulates sulfotransferase activity, leading to increased sulfation of substrates. This results in the up-regulation of Sult2a4 expression, supporting its predicted role in cytoplasmic sulfation processes associated with triterpenoid metabolism. | ||||||