SULT2A1 Activators
SULT2A1 Activators are a class of compounds that enhance the functional activity of the SULT2A1 protein. They operate primarily through the activation of the nuclear factorerythroid 2-related factor 2 (Nrf2) pathway, a critical regulator of cellular resistance to oxidants. Upon activation by these compounds, Nrf2 migrates to the nucleus and binds to antioxidant response elements (AREs) in the promoter regions of many detoxification and antioxidant genes, including SULT2A1. This binding event triggers the transcriptional activation of SULT2A1, leading to an increase in its functional activity. The compounds in this class are chemically diverse, including various polyphenolic compounds, flavonoids, carotenoids, and isoflavones, each with unique structural characteristics that enable them to activate the Nrf2 pathway.
The SULT2A1 protein is a member of the sulfotransferase family, enzymes responsible for the sulfation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. Its activity is crucial for the metabolism and detoxification of these substances. The SULT2A1 Activators, through their activation of the Nrf2 pathway, ensure that SULT2A1 is available in sufficient quantities to carry out its detoxifying role. This is especially crucial under conditions of oxidative stress or exposure to harmful substances. By enhancing SULT2A1's functional activity, these compounds contribute to maintaining cellular homeostasis and protecting the cell from damage. Each of the chemicals in this class, despite their structural diversity, operate on this same fundamental principle of Nrf2 pathway activation, making them collectively powerful amplifiers of SULT2A1's functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables that has the capacity to upregulate phase II detoxification enzymes, including SULT2A1, through the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. The activation of this pathway leads to the binding of Nrf2 to antioxidant response elements (AREs) in the promoter regions of detoxification genes, including SULT2A1, thereby enhancing their functional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a polyphenolic compound found in turmeric with multiple biological activities. It can activate the Nrf2 pathway, leading to enhanced expression and functional activity of phase II detoxification enzymes, including SULT2A1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes. It can activate the Nrf2 pathway, leading to increased expression and functional activity of phase II detoxification enzymes, including SULT2A1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid found in many plants and foods. It can activate the Nrf2 pathway, thereby enhancing the expression and functional activity of phase II detoxification enzymes, including SULT2A1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate is the most abundant catechin in green tea. It can activate the Nrf2 pathway, leading to the increased expression and functional activity of phase II detoxification enzymes, including SULT2A1. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $146.00 $582.00 $6248.00 | 4 | |
Lycopene is a carotenoid found in tomatoes. It can activate the Nrf2 pathway, leading to enhanced expression and functional activity of phase II detoxification enzymes, including SULT2A1. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol is a natural flavonol found in many fruits and vegetables. It can activate the Nrf2 pathway, leading to increased expression and functional activity of phase II detoxification enzymes, including SULT2A1. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $97.00 $188.00 $260.00 $510.00 $1022.00 | 3 | |
Myricetin is a flavonoid found in many berries and vegetables. It can activate the Nrf2 pathway, enhancing the expression and functional activity of phase II detoxification enzymes, including SULT2A1. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin is a flavone found in parsley and green peppers. It can activate the Nrf2 pathway, enhancing the expression and functional activity of phase II detoxification enzymes, including SULT2A1. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone found in soy. It can activate the Nrf2 pathway, leading to increased expression and functional activity of phase II detoxification enzymes, including SULT2A1. | ||||||