SUHW3 Inhibitors
SUHW3 inhibitors employ a variety of biochemical mechanisms to reduce the activity of this transcription factor. Some inhibitors work by modifying the epigenetic landscape, such as those that prevent histone deacetylation or DNA methylation. This results in a more open chromatin structure and altered gene expression profiles, which may lead to a decrease in SUHW3 levels or its recruitment to target genes. Other compounds target protein degradation pathways, such as the ubiquitin-proteasome system, thus potentially leading to the accumulation of proteins that compete with or negatively regulate SUHW3's function. Additionally, inhibitors that block nuclear export can sequester interacting transcription factors in the nucleus, again potentially diminishing SUHW3's transcriptional activity.
Another group of SUHW3 inhibitors interfere with signal transduction pathways that are crucial for the proper functioning and regulation of transcription factors. For example, compounds that inhibit PI3K, MEK, or JNK can disrupt downstream signaling events that ultimately affect the stability, localization, or activity of transcription factors, indirectly influencing SUHW3's role in gene expression. Inhibitors of mTOR signaling can impact the translational machinery, which might alter the expression levels of crucial transcriptional regulators and thereby affect SUHW3's activity. Furthermore, inhibition of specific signaling pathways like Hedgehog, TGF-beta, and Wnt/β-catenin can alter the transcriptional landscape in a way that influences the activity or expression of SUHW3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that increases acetylation of histones, leading to changes in chromatin structure and decreased gene expression, including genes encoding transcription factors like SUHW3. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
DNA methyltransferase inhibitor that reduces methylation levels, altering gene expression patterns that can lead to reduced levels of transcription factors such as SUHW3. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially causing reduced availability of transcriptional regulators that interact with SUHW3, influencing its activity. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Hedgehog signaling pathway inhibitor that affects transcription factors downstream of the pathway, which may interact with or regulate SUHW3. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
A histone deacetylase inhibitor that leads to open chromatin and can decrease the expression of specific genes, possibly including those encoding transcription factors like SUHW3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that affects the AKT signaling pathway, which can regulate transcription factor stability and localization, indirectly affecting SUHW3's function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor that modulates transcriptional programs by affecting protein synthesis, potentially altering the expression and function of transcription factors including SUHW3. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
CRM1/exportin 1 inhibitor that blocks nuclear export of certain transcription factors, possibly affecting their interaction with SUHW3. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor that interferes with the MAPK/ERK pathway, potentially altering transcription factor activity and thereby modulating SUHW3's role in gene expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that can modulate transcriptional responses influenced by stress-activated pathways, potentially affecting SUHW3's activity. | ||||||