Date published: 2026-4-20

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Stat Inhibitors

STAT Inhibitors represent a class of chemicals that interfere with the activation and function of Signal Transducer and Activator of Transcription (STAT) proteins. These inhibitors are diverse in structure and mechanism of action, reflecting the complexity of STAT protein regulation. They target various stages in the STAT signaling pathway, from initial activation to nuclear translocation. Compounds like Stattic and WP1066 exemplify the direct targeting of STAT proteins. Stattic selectively inhibits STAT3 by preventing its activation, dimerization, and nuclear translocation, while WP1066 inhibits both JAK2 and STAT3, thwarting the phosphorylation and subsequent activation of STAT proteins. In contrast, AG490 and AZD1480 operate as tyrosine kinase inhibitors, with a focus on inhibiting JAK2, a kinase that phosphorylates STAT proteins. By inhibiting JAK2, these compounds indirectly prevent STAT activation. Additionally, molecules like Curcumin and Niclosamide showcase the multifaceted nature of cellular signaling. While Curcumin is known for its various effects on cellular pathways, in some contexts, it can inhibit STAT3 activation. Niclosamide, primarily an anthelmintic drug, demonstrates the potential for existing drugs to have unexpected effects on signaling pathways, including the inhibition of STAT3.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Fludarabine

21679-14-1sc-204755
sc-204755A
5 mg
25 mg
$58.00
$204.00
15
(1)

A nucleotide analog that can inhibit DNA synthesis. It may indirectly inhibit STAT activation by altering cellular signaling pathways involved in cell proliferation and response to cytokines.

Chromeo™ 546 alkyne

sc-364708
1 mg
$298.00
(0)

Chromeo™ 546 alkyne is a specialized compound characterized by its unique reactivity as an acid halide. It exhibits rapid reaction kinetics, particularly in nucleophilic substitution processes, due to the electrophilic nature of its carbonyl group. The compound's linear structure allows for efficient π-stacking interactions, enhancing its stability in certain environments. Additionally, its ability to form stable adducts with various nucleophiles highlights its versatility in synthetic pathways, making it a key player in organic transformations.

Stat3 inhibitor V, stattic

19983-44-9sc-202818
sc-202818A
sc-202818B
sc-202818C
sc-202818D
sc-202818E
sc-202818F
25 mg
100 mg
250 mg
500 mg
1 g
2.5 g
5 g
$130.00
$196.00
$274.00
$512.00
$731.00
$1408.00
$2091.00
114
(3)

Known to selectively inhibit the activation, dimerization, and nuclear translocation of STAT3, a member of the STAT family.

Tyrphostin B42

133550-30-8sc-3556
5 mg
$26.00
4
(1)

A tyrosine kinase inhibitor that can inhibit JAK2, potentially preventing the phosphorylation and activation of STAT proteins.

Stat3 Inhibitor III, WP1066

857064-38-1sc-203282
10 mg
$132.00
72
(1)

An inhibitor of JAK2 and STAT3, it can prevent the phosphorylation and subsequent activation of STAT proteins.

Cryptotanshinone

35825-57-1sc-280649
10 mg
$119.00
1
(1)

A compound known to inhibit STAT3 phosphorylation and dimerization, potentially blocking STAT signaling pathways.

Niclosamide

50-65-7sc-250564
sc-250564A
sc-250564B
sc-250564C
sc-250564D
sc-250564E
100 mg
1 g
10 g
100 g
1 kg
5 kg
$38.00
$79.00
$188.00
$520.00
$1248.00
$5930.00
8
(1)

An anthelmintic drug that can also inhibit STAT3 signaling pathway in certain cellular contexts.

Stat3 Inhibitor VI, S3I-201

501919-59-1sc-204304
10 mg
$151.00
104
(1)

Known to block the dimerization of STAT3, thereby inhibiting its activity.

AZD1480

935666-88-9sc-364735
sc-364735A
5 mg
50 mg
$124.00
$1072.00
11
(2)

A JAK2 inhibitor, which can impede the activation of STAT proteins by preventing their phosphorylation.

Piceatannol

10083-24-6sc-200610
sc-200610A
sc-200610B
1 mg
5 mg
25 mg
$51.00
$71.00
$199.00
11
(2)

An inhibitor of Syk kinase, which can indirectly affect STAT signaling pathways.