SRp55 Inhibitors
SRp55 inhibitors are a class of chemical compounds designed to target and modulate the activity of the SRp55 protein. SRp55, also known as Serine/arginine-rich splicing factor 6 (SRSF6), is a member of the serine/arginine-rich (SR) protein family, which plays a crucial role in pre-mRNA splicing. Pre-mRNA splicing is a fundamental process in eukaryotic cells that involves the removal of introns and the joining of exons to create mature mRNA molecules, which subsequently guide protein synthesis. SRp55 is specifically involved in the recognition and binding of RNA sequences, facilitating the spliceosome assembly and regulating alternative splicing patterns in various genes.
SRp55 inhibitors are designed to disrupt the normal functioning of SRp55, thereby influencing the splicing of specific target genes. These inhibitors typically work by binding to SRp55 and interfering with its RNA-binding ability or its interactions with other splicing factors. By doing so, they can modulate the alternative splicing patterns of target genes, leading to the production of alternative mRNA isoforms or even exon skipping. This ability to manipulate gene expression at the post-transcriptional level can have significant implications for cellular processes, as it allows for the generation of diverse protein isoforms with distinct functions or regulatory properties. SRp55 inhibitors are therefore valuable tools in molecular biology research, enabling scientists to study the functional consequences of specific splicing events and better understand the role of alternative splicing in gene regulation and cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil is a pyrimidine analog that can be incorporated into RNA and DNA, potentially leading to the inhibition of thymidylate synthase and disruption of DNA synthesis and function, possibly affecting SRp55 expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA and disrupts DNA-dependent RNA synthesis. This interaction can inhibit RNA polymerase, potentially reducing the transcription of various genes, including SRp55. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits protein synthesis at the level of translation. While it primarily affects global protein synthesis, it can indirectly influence the stability and expression of specific proteins like SRp55. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR) pathway, which is involved in protein synthesis and cell growth. By doing so, it can potentially influence the expression of proteins, including SRp55. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide interferes with the function of topoisomerase II, an enzyme crucial for DNA replication and repair. This interference can lead to DNA damage and potentially affect gene expression, including SRp55. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to influence various signaling pathways and transcription factors. It has the potential to modulate gene expression, potentially impacting the levels of SRp55. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to modulate various signaling pathways and transcription factors. It can potentially alter the expression of numerous genes, including SRp55. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This compound is a major catechin found in green tea and has been shown to influence various signaling pathways. It has the potential to modulate gene expression, potentially affecting SRp55 levels. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is an Hsp90 inhibitor, and Hsp90 is known to be involved in the stability and function of a variety of proteins. Inhibiting Hsp90 can potentially affect the expression and activity of proteins, including SRp55. | ||||||