SR-β Inhibitors
SR-β inhibitors are chemical compounds designed to specifically target and inhibit the activity of the signal recognition particle receptor beta subunit (SR-β), a key component of the protein translocation machinery. SR-β, along with its alpha counterpart (SR-α), forms part of the signal recognition particle (SRP) receptor complex, which is responsible for directing newly synthesized proteins to the endoplasmic reticulum (ER) for proper folding and processing. This system is crucial for the translocation of proteins that are destined for secretion or incorporation into cellular membranes. SR-β plays a role in anchoring the SRP receptor to the ER membrane and assisting in the coordination between SRP and SR-α during protein targeting. Inhibitors of SR-β interfere with these functions, potentially disrupting the entire process of protein targeting and translocation.
By inhibiting SR-β, researchers can study how the disruption of protein targeting affects the broader cellular processes dependent on proper protein localization and membrane integration. SR-β inhibitors offer a way to dissect the step-by-step functions of the SRP receptor complex and the role of SR-β in coordinating the delivery of ribosome-bound nascent polypeptides to the ER. This inhibition allows for an investigation into how defects in SRP-mediated translocation impact protein synthesis, folding, and cellular homeostasis. Through the application of SR-β inhibitors, scientists gain a more nuanced understanding of the intricacies of protein sorting and how SR-β contributes to the efficient management of protein trafficking within the cell. These inhibitors are valuable tools in molecular biology research, particularly in the study of protein biogenesis and transmembrane transport systems.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin might affect protein synthesis and could indirectly influence the expression or function of SRβ. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Known to inhibit protein synthesis in eukaryotic organisms, potentially affecting SRβ levels. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
An Hsp90 inhibitor that could disrupt various cellular proteins and potentially SRβ function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that might prevent the degradation of misfolded SRβ, affecting its levels. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
As an RNA synthesis inhibitor, it could indirectly affect SRβ protein synthesis. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A kinase inhibitor that might influence various cellular pathways, potentially affecting SRβ function indirectly. | ||||||
Chloroquine Sulphate | 132-73-0 | sc-337629 | 25 mg | $224.00 | 2 | |
Known to affect endosomal function; could indirectly influence SRβ-associated pathways. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts protein transport from the ER to the Golgi, potentially affecting SRβ function. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Interferes with DNA and RNA synthesis, which might indirectly affect SRβ expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Inhibits RNA synthesis and might affect SRβ expression indirectly. | ||||||