Date published: 2025-9-7

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SR-5A Inhibitors

SR-5A inhibitors, or 5-alpha reductase inhibitors, comprise a diverse and fascinating class of chemical entities that exert a profound influence on the endocrine system by specifically targeting the activity of the enzyme 5-alpha reductase (5AR or SRD5A). This class of enzymes, primarily SRD5A1 and SRD5A2, plays an indispensable role in mediating the conversion of testosterone, the principal male sex hormone, into dihydrotestosterone (DHT), a potent androgen with a myriad of biological effects. DHT is known for its crucial involvement in the development of male secondary sexual characteristics, the maintenance of prostate gland function, and the regulation of hair growth patterns. SR-5A inhibitors are meticulously engineered or naturally derived compounds designed to intercept or modulate this enzymatic conversion, thereby intricately influencing the endogenous levels of DHT.From a chemical perspective, SR-5A inhibitors encompass a broad spectrum of substances, ranging from synthetically designed to naturally occurring compounds found in various botanical sources. The mechanism of action of these inhibitors is centered around their capacity to disrupt the enzymatic activity of 5AR, leading to a reduction in the production of DHT. Synthetic SR-5A inhibitors like finasteride and dutasteride have achieved widespread recognition for their pivotal roles in the management of androgenetic alopecia (male pattern baldness) and benign prostatic hyperplasia (BPH). The comprehensive comprehension of SR-5A inhibitors is essential not only for their established applications but also for unraveling their implications in the broader realm of endocrine regulation and hormone-related research endeavors.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SB 699551 dihydrochloride

864741-95-7sc-361349
sc-361349A
5 mg
25 mg
$142.00
$797.00
(0)

SB 699551 dihydrochloride functions as an SR-5A inhibitor, exhibiting distinctive reactivity patterns as an acid halide. Its unique structural features facilitate specific interactions with target enzymes, modulating their activity through competitive binding. The compound's electronic configuration allows for rapid nucleophilic attack, influencing reaction kinetics. Additionally, its solubility characteristics can alter the dynamics of molecular interactions, providing insights into its mechanistic behavior in various chemical environments.

Finasteride

98319-26-7sc-203954
50 mg
$103.00
3
(1)

Finasteride is a well-known SR-5a inhibitor that is investigated for its use for BPH and androgenetic alopecia. It works by inhibiting the action of SRD5A2, one of the isoforms of the enzyme.

Methiothepin maleate

19728-88-2sc-203630
50 mg
$133.00
1
(1)

Methiothepin maleate acts as an SR-5A inhibitor, characterized by its ability to engage in selective molecular interactions that disrupt receptor signaling pathways. Its unique stereochemistry enhances binding affinity, allowing for effective modulation of target proteins. The compound's dynamic conformational changes contribute to its reactivity, while its hydrophilic properties influence solvation effects, impacting overall interaction profiles in diverse biochemical contexts.

Dimebolin dihydrochloride

97657-92-6sc-294348
sc-294348A
sc-294348B
1 mg
5 mg
50 mg
$37.00
$96.00
$384.00
(0)

Dimebolin dihydrochloride functions as an SR-5A inhibitor, distinguished by its capacity to form specific hydrogen bonds with target receptors, thereby altering their conformational states. This compound exhibits unique electronic properties that facilitate charge transfer during interactions, enhancing its reactivity. Additionally, its solubility characteristics allow for effective diffusion in various environments, influencing kinetic pathways and interaction dynamics within complex biological systems.

Dutasteride

164656-23-9sc-207600
10 mg
$167.00
2
(1)

Dutasteride is another approved SR-5a inhibitor. It inhibits both SRD5A1 and SRD5A2 isoforms, leading to a more comprehensive reduction in DHT levels.

Asenapine maleate

65576-45-6sc-361110
sc-361110A
10 mg
50 mg
$145.00
$615.00
(0)

Asenapine maleate acts as an SR-5A inhibitor, characterized by its ability to engage in selective π-π stacking interactions with aromatic residues in target proteins. This compound demonstrates unique steric hindrance that influences binding affinity and specificity. Its amphiphilic nature enhances membrane permeability, allowing for rapid localization within cellular compartments. Furthermore, the compound's dynamic conformational flexibility plays a crucial role in modulating interaction kinetics and stability in diverse biochemical contexts.

Lycopene

502-65-8sc-205738
sc-205738A
sc-205738B
1 mg
5 mg
1 g
$143.00
$571.00
$6125.00
4
(1)

Lycopene is a carotenoid found in tomatoes and other red fruits. Some studies suggest it may have SR-5a inhibitory effects and could be beneficial for prostate health.

β-Sitosterol

83-46-5sc-204432
sc-204432A
10 g
25 g
$60.00
$213.00
5
(1)

Beta-sitosterol is a plant sterol found in various foods and supplements. It has been studied for its potential SR-5a inhibitory properties and its use in BPH management.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

Green tea contains compounds called catechins, which have been investigated for their SR-5a inhibitory effects and their potential role in prostate health.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
5 g
100 g
250 g
1 kg
5 kg
$32.00
$66.00
$95.00
$188.00
$760.00
13
(1)

Some studies suggest that caffeine may have SR-5a inhibitory effects, which could be relevant to its use in hair loss prevention shampoos.