Molecular structure of Methiothepin maleate, CAS Number: 19728-88-2
Methiothepin maleate (CAS 19728-88-2)
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Alternate Names:
Metitepine maleate; 1-[10,11-Dihydro-8-(methylthio)dibenzo(Z)[b,f]thiepin-10-yl]-4-methylpiperazine maleate
Application:
Methiothepin maleate is a potent 5-HT2 and active 5-HT1 antagonist
CAS Number:
19728-88-2
Purity:
≥98%
Molecular Weight:
472.62
Molecular Formula:
C20H24N2S2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Methiothepin maleate is a serotonin receptor antagonist that functions by blocking the activity of serotonin at the receptor site. It acts as a competitive antagonist at 5-HT2A and 5-HT2C receptors, inhibiting the binding of serotonin and preventing its downstream signaling. Methiothepin Maleate′s mechanism of action involves interfering with the normal physiological effects of serotonin, thereby altering neurotransmission and modulating various physiological processes. Methiothepin Maleate′s mechanism of action at the molecular level involves its ability to bind to serotonin receptors and prevent their activation by serotonin, thereby providing insights into the role of serotonin in cellular and physiological functions.
Methiothepin maleate (CAS 19728-88-2) References
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- Activation of presynaptic 5-hydroxytryptamine1-like receptors on glutamatergic terminals inhibits N-methyl-D-aspartate-induced cyclic GMP production in rat cerebellar slices. | Raiteri, M., et al. 1991. J Pharmacol Exp Ther. 257: 1184-8. PMID: 1675289
- Methiothepin-sensitive serotonin receptors are involved in the postsynaptic mechanism of sensitization of the defensive response in the common snail. | Abramova, MS., et al. 2006. Neurosci Behav Physiol. 36: 589-96. PMID: 16783511
- Effect of duloxetine, a norepinephrine and serotonin reuptake inhibitor, on sneeze-induced urethral continence reflex in rats. | Miyazato, M., et al. 2008. Am J Physiol Renal Physiol. 295: F264-71. PMID: 18480175
- The influence of adrenergic, dopaminergic, cholinergic and serotoninergic drugs on plasma prolactin levels in ovariectomized, estrogen-treated rats. | Lawson, DM. and Gala, RR. 1975. Endocrinology. 96: 313-8. PMID: 234380
- Modulation of the subthalamic nucleus activity by serotonergic agents and fluoxetine administration. | Aristieta, A., et al. 2014. Psychopharmacology (Berl). 231: 1913-24. PMID: 24271033
- Antifungal application of nonantifungal drugs. | Stylianou, M., et al. 2014. Antimicrob Agents Chemother. 58: 1055-62. PMID: 24277040
- 5-HT3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret. | Higgins, GA., et al. 1989. Br J Pharmacol. 97: 247-55. PMID: 2720310
- Convergent synaptic inputs to layer 1 cells of mouse cortex. | Lam, YW. and Sherman, SM. 2019. Eur J Neurosci. 49: 1388-1399. PMID: 30585669
- Action of the serotoninergic and dopaminergic antagonist methiothepin maleate on serum prolactin and growth hormone levels in man. | Masala, A., et al. 1979. Panminerva Med. 21: 65-8. PMID: 554040
- Discriminative stimulus properties of pizotifen maleate (BC105): a putative serotonin antagonist. | Minnema, DJ., et al. 1984. Psychopharmacology (Berl). 83: 200-4. PMID: 6431474
- Screening of antiserotoninergic drugs with the genetically dystrophic chicken. | Hudecki, MS., et al. 1980. Arch Neurol. 37: 545-50. PMID: 6448038
- 5-Hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways. | Takahashi, T., et al. 1995. Am J Respir Crit Care Med. 152: 377-80. PMID: 7599849
Inhibitor of:
SR-4, SR-5A, SR-5B, SR-6, and SR-7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Methiothepin maleate, 50 mg | sc-203630 | 50 mg | $136.00 | |||
| US: Only available in the US | ||||||