Date published: 2026-4-30

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SR-5A Activators

SR-5A Activators comprise a distinct class of chemical compounds that function to augment the functional activity of SR-5A, a protein that plays a pivotal role in multiple signaling pathways. These activators primarily operate through interactions with the HTR1A (5-HT1A) receptor, a critical component in the regulatory mechanism of SR-5A. Activators of this class function by activating the 5-HT1A receptor, leading to a reduction in adenylate cyclase activity and cAMP levels. This action is facilitated through the stimulation of an inhibitory G protein, whichsubsequently enhances the functionality of SR-5A. In contrast, activators can also enhance the functional activity of SR-5A by increasing the availability of serotonin in the synaptic cleft. This increase in serotonin availability fosters an environment that can enhance signaling pathways leading to SR-5A activation. The collective action of the SR-5A activators is a testament to the intricate and complex network of biochemical reactions that regulate SR-5A's function. It is important to note that these chemicals do not universally act to increase SR-5A activation, but rather demonstrate a diverse array of mechanisms that can result in enhancement of SR-5A functionality. These distinct mechanisms highlight the multi-faceted nature of protein regulation and emphasize the importance of understanding the specific biochemical and cellular pathways through which these chemicals operate. The precise mechanisms by which these chemicals achieve enhancement of SR-5A function provide a valuable framework for further exploration of SR-5A's role and regulation within the cellular environment.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Valerenic acid

3569-10-6sc-204377
sc-204377A
1 mg
10 mg
$72.00
$483.00
1
(1)

Valerenic acid, recognized as an SR-5A activator, showcases remarkable reactivity as an acid halide through its ability to engage in selective acylation processes. Its unique steric and electronic properties enable it to interact effectively with a range of nucleophiles, leading to diverse reaction pathways. The compound's conformational flexibility enhances its reactivity, while its solvation dynamics can significantly influence the rate and outcome of chemical transformations, making it a subject of interest in mechanistic studies.

5-Carboxamidotryptamine maleate

74885-09-9sc-203477
sc-203477A
5 mg
25 mg
$302.00
$1086.00
2
(0)

5-CT is a potent agonist of the 5-HT1A receptor, which is known to be indirectly involved in SR-5A activation. By activating the 5-HT1A receptor, it stimulates an inhibitory G protein, reducing adenylate cyclase activity and cAMP levels, which can enhance SR-5A functionality.

NAN-190

115338-32-4sc-201138
sc-201138A
50 mg
250 mg
$77.00
$436.00
(0)

NAN-190 is a 5-HT1A receptor antagonist. It can indirectly enhance the function of SR-5A by increasing the availability of serotonin in the synapse which can enhance the signaling that leads to SR-5A activation.

Buspirone

36505-84-7sc-504347
2.5 g
$301.00
1
(0)

Buspirone is a 5-HT1A receptor partial agonist. It can activate the receptor, leading to a reduction in adenylate cyclase activity and cAMP levels through stimulation of an inhibitory G protein, indirectly enhancing SR-5A activity.

Tandospirone hydrochloride

99095-10-0sc-204320
sc-204320A
10 mg
50 mg
$132.00
$559.00
(0)

Tandospirone is a partial agonist of the 5-HT1A receptor. It activates the receptor, stimulating an inhibitory G protein to suppress adenylate cyclase activity and decrease cAMP levels, indirectly enhancing SR-5A activity.

Vilazodone

163521-12-8sc-364756
sc-364756A
10 mg
50 mg
$213.00
$785.00
(0)

Vilazodone is a 5-HT1A receptor partial agonist. It can activate the receptor, leading to a reduction in adenylate cyclase activity and cAMP levels through stimulation of an inhibitory G protein, indirectly enhancing SR-5A activity.

Tyrphostin B42

133550-30-8sc-3556
5 mg
$26.00
4
(1)

Eptapirone is a potent and selective 5-HT1A agonist. It can activate the receptor, stimulating an inhibitory G protein and leading to a reduction in adenylate cyclase activity and cAMP levels, indirectly enhancing SR-5A activity.