Molecular structure of NAN-190, CAS Number: 115338-32-4
NAN-190 (CAS 115338-32-4)
Alternate Names:
NAN-190 hydrobromide
Application:
NAN-190 is a potent serotonin SR-1A antagonist
CAS Number:
115338-32-4
Purity:
>98%
Molecular Weight:
474.4
Molecular Formula:
C23H27N3O3•HBr
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NAN-190 is a SR-1A antagonist.
NAN-190 (CAS 115338-32-4) References
- On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists. | Paluchowska, MH., et al. 1999. J Med Chem. 42: 4952-60. PMID: 10585205
- 5-Hydroxytryptamine-induced outward currents mediated via 5-HT(1A) receptors in neurons of the rat dorsolateral septal nucleus. | Yamada, K., et al. 2000. Neurosci Res. 37: 307-14. PMID: 10958979
- Evidence that NAN-190-induced hypotension involves vascular alpha1-adrenoceptor antagonism in the rat. | Villalobos-Molina, R., et al. 2002. Eur J Pharmacol. 455: 59-64. PMID: 12433595
- NAN-190, a possible specific antagonist for methamphetamine. | Ginawi, OT., et al. 2005. Regul Toxicol Pharmacol. 41: 122-7. PMID: 15698535
- Enhancement of photic shifts with the 5-HT1A mixed agonist/antagonist NAN-190: intra-suprachiasmatic nucleus pathway. | Sterniczuk, R., et al. 2008. Neuroscience. 153: 571-80. PMID: 18406538
- NAN-190 potentiates the circadian response to light and speeds re-entrainment to advanced light cycles. | Kessler, EJ., et al. 2008. Neuroscience. 154: 1187-94. PMID: 18538936
- 5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig. | Foong, JP. and Bornstein, JC. 2009. Neuroreport. 20: 325-30. PMID: 19190523
- Effects of 8-OH-DPAT and NAN-190 on anxious-depressive-like behavior of female rats during the estrous cycle. | Fedotova, YO. and Ordyan, NE. 2010. Bull Exp Biol Med. 150: 165-7. PMID: 21246079
- The behavioural, but not the hypothermic or corticosterone, response to 8-hydroxy-2-(DI-n-propylamino)-tetralin, is antagonized by NAN-190 in the rat. | Przegaliński, E., et al. 1990. Neuropharmacology. 29: 521-6. PMID: 2143565
- NAN-190: agonist and antagonist interactions with brain 5-HT1A receptors. | Rydelek-Fitzgerald, L., et al. 1990. Brain Res. 532: 191-6. PMID: 2282513
- Mixed agonist/antagonist properties of NAN-190 at 5-HT1A receptors: behavioural and in vivo brain microdialysis studies. | Hjorth, S. and Sharp, T. 1990. Life Sci. 46: 955-63. PMID: 2329921
- NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). | Glennon, RA., et al. 1988. Eur J Pharmacol. 154: 339-41. PMID: 2976673
- Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands. | Glennon, RA., et al. 1988. J Med Chem. 31: 1968-71. PMID: 3172131
Inhibitor of:
SR-1A.Activator of:
SR-5A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NAN-190, 50 mg | sc-201138 | 50 mg | $77.00 | |||
NAN-190, 250 mg | sc-201138A | 250 mg | $436.00 |